Francis R M, Peacock M, Marshall D H, Horsman A, Aaron J E
Newcastle General Hospital, England.
Bone Miner. 1989 Mar;5(3):347-57. doi: 10.1016/0169-6009(89)90012-3.
In 94 men with crush fracture, 40 were found to have primary osteoporosis. Cross-sectional measurements of a number of variables related to bone in these 40 patients were compared to the values in various groups of healthy men aged 20-96. In healthy men, metacarpal and femoral cortical area/total area, bone volume, osteoid surfaces, seam and trabecular width, plasma dihydroepiandrosterone and estrone, and radiocalcium absorption fell with age, whereas eroded surfaces, trabecular number, urine hydroxyproline and calcium/creatinine ratios, plasma alkaline phosphatase, estradiol, androstenedione, cortisol and testosterone remained constant with age. As compared with healthy men, men with primary osteoporosis had reduced femoral cortical area/total area (P less than 0.05), and Singh grade (P less than 0.001) and in seven there was a history of forearm or femoral fracture. On iliac crest biopsy, bone volume (P less than 0.001) and trabecular number (P less than 0.01) were decreased. Plasma alkaline phosphatase (P less than 0.02) was increased but urine hydroxyproline and calcium excretion were not significantly raised. Calcium balance was negative due to failure of absorption to match urinary calcium loss and radiocalcium absorption (P less than 0.01) and plasma 1,25-dihydroxyvitamin D (P less than 0.05) were reduced.
在94例患有压缩性骨折的男性中，发现40例患有原发性骨质疏松症。将这40例患者中一些与骨骼相关变量的横断面测量值与20 - 96岁不同健康男性组的值进行比较。在健康男性中，掌骨和股骨皮质面积/总面积、骨体积、类骨质表面、骨缝和小梁宽度、血浆脱氢表雄酮和雌酮以及放射性钙吸收随年龄下降，而侵蚀表面、小梁数量、尿羟脯氨酸和钙/肌酐比值、血浆碱性磷酸酶、雌二醇、雄烯二酮、皮质醇和睾酮随年龄保持恒定。与健康男性相比，原发性骨质疏松症男性的股骨皮质面积/总面积降低（P < 0.05），辛格分级降低（P < 0.001），并且7例有前臂或股骨骨折史。在髂嵴活检中，骨体积（P < 0.001）和小梁数量（P < 0.01）减少。血浆碱性磷酸酶升高（P < 0.02），但尿羟脯氨酸和钙排泄未显著升高。由于吸收未能与尿钙流失相匹配，钙平衡为负，放射性钙吸收降低（P < 0.01），血浆1,25 - 二羟维生素D降低（P < 0.05）。
