Resch H, Pietschmann P, Woloszczuk W, Krexner E, Bernecker P, Willvonseder R
Department of Medicine, Krankenhaus Barmherzige Brüder, Vienna, Austria.
Eur J Clin Invest. 1992 Aug;22(8):542-5. doi: 10.1111/j.1365-2362.1992.tb01503.x.
With advancing age both sexes have an increased incidence of osteoporotic fractures, although fractures are more common in women than in men. Whereas in women several potential risk factors have been identified, less is known about osteoporosis in men. A total of 27 Austrian men (mean age: 65 +/- 2 years) with atraumatic spine fractures were studied. In all patients, medical history gave no evidence of disease or medications causing osteoporosis. Peripheral bone mass was determined by single-photonabsorptiometry on the distal non-dominant forearm; lumbal bone density was measured by quantitative computed tomography. Serum levels of calcium, phosphate, alkaline phosphatase, osteocalcin, testosterone, estrogen, parathyroid hormone and 25-hydroxy-vitamin D as well as 2-h-urinary-OH proline and calcium excretion were measured. All data were compared with those of an age and sex matched control group consisting of 19 healthy males. A significant difference in mean peripheral and axial bone mass (SPA: P less than 0.004; QCT: P less than 0.0001) was observed between osteoporotic men and controls. When compared to controls, serum levels of alkaline phosphatase (P less than 0.012), urinary OH proline (P less than 0.05) and urinary calcium excretion (P less than 0.003) were significantly higher in the osteoporotic males. Additionally, there was a significant positive correlation between serum alkaline phosphatase and urinary OH proline excretion (r = 0.32; P less than 0.04) in the osteoporotics. All other biochemical parameters showed no significant differences. Our results may lead to the assumption that osteopenia in men is related to increased bone turnover.
随着年龄的增长，骨质疏松性骨折的发病率在两性中均有所上升，尽管女性骨折比男性更为常见。虽然已确定女性存在多种潜在风险因素，但对于男性骨质疏松症的了解却较少。本研究共纳入了27名患有非创伤性脊柱骨折的奥地利男性（平均年龄：65±2岁）。所有患者的病史均未显示有导致骨质疏松症的疾病或药物。通过单光子吸收法测量非优势侧远端前臂的外周骨量；通过定量计算机断层扫描测量腰椎骨密度。检测血清钙、磷、碱性磷酸酶、骨钙素、睾酮、雌激素、甲状旁腺激素和25-羟基维生素D水平，以及2小时尿羟脯氨酸和钙排泄量。所有数据均与由19名健康男性组成的年龄和性别匹配的对照组进行比较。观察到骨质疏松男性与对照组之间在外周和轴向骨量方面存在显著差异（单光子吸收法：P<0.004；定量计算机断层扫描：P<0.0001）。与对照组相比，骨质疏松男性的血清碱性磷酸酶水平（P<0.012）、尿羟脯氨酸水平（P<0.05）和尿钙排泄量（P<0.003）显著更高。此外，骨质疏松患者血清碱性磷酸酶与尿羟脯氨酸排泄之间存在显著正相关（r = 0.32；P<0.04）。所有其他生化参数均无显著差异。我们的结果可能导致这样一种假设，即男性骨质减少与骨转换增加有关。
