正常大鼠和贫血大鼠肌肉注射14C标记的铁-聚（山梨醇-葡萄糖酸）复合物后碳水化合物聚合物的分布情况。
Distribution of the carbohydrate polymer in 14C-labelled iron-poly (sorbitol-gluconic acid) complex after intramuscular administration in normal and anaemic rats.
作者信息
Gagner-Milchert I, Lindvall S, Rydell G
出版信息
Scand J Haematol Suppl. 1977;32:136-48. doi: 10.1111/j.1600-0609.1977.tb01227.x.
The carbohydrate polymer in an iron-poly (sorbitol-gluconic acid) complex was prepared by using uniformly labelled 14C-sorbitol or 14C-gluconic acid. The distribution of these complexes 7, 14 and 28 days after administration has been followed in non-anaemic and anaemic rats. Most of the 14C from the labelled complexes was found in the expired CO2, faeces and urine. Twenty-eight days after injection of 14C-labelled Ferastral, less than 13% of the given dose of either 14C-sorbitol or 14C-gluconic acid labelled preparation could be found in the body. There was no specific accumulation of 14C in any organ except in the bones, where 3% of the given dose could be seen 28 days after 14C-gluconic acid labelled Ferastral to both non-anaemic and anaemic animals.
铁-聚（山梨醇-葡萄糖酸）复合物中的碳水化合物聚合物是通过使用均匀标记的14C-山梨醇或14C-葡萄糖酸制备的。在非贫血和贫血大鼠中，已追踪了给药后7天、14天和28天这些复合物的分布情况。标记复合物中的大部分14C存在于呼出的二氧化碳、粪便和尿液中。注射14C标记的费拉斯屈（Ferastral）28天后，在体内发现14C-山梨醇或14C-葡萄糖酸标记制剂的给药剂量不到13%。除骨骼外，14C在任何器官中均无特异性蓄积，在给非贫血和贫血动物注射14C-葡萄糖酸标记的费拉斯屈28天后，骨骼中可见给药剂量的3%。
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