Magnusson G, Flodh H, Malmfors T
Scand J Haematol Suppl. 1977;32:87-98. doi: 10.1111/j.1600-0609.1977.tb01220.x.
Four groups of Sprague-Dawley rats were given Ferastral, an iron-poly(sorbitol-gluconic acid) complex (IPSG) or Imferon, an iron-dextran complex, intramuscularly twice a week for 17 weeks. The experiment lasted for 95 weeks. Each compound was given to two groups, one low dose group and one high dose group. Depending on the body mass, the dose levels varied between 2.5 and 10 mg (25-50 mg/kg body mass) and between 5 and 20 mg (50-100 mg/kg body mass) of iron per rat, respectively. The mean total dose of iron per rat was calculated to be 235 and 495 mg, respectively. Another group of animals served as a control. From about the 30th experimental week onwards tumours developed at the intramuscular injection sites in the groups given Ferastral and Imferon. The tumours appeared to be sarcomas. In almost all the treated animals that lived longer than 30 weeks after the start of the experiment, sarcomas were present at the intramuscular injection sites. The sarcomas appeared earlier in the high dose groups than in the low dose groups and slightly earlier in the rats given Ferastral than in those given Imferon. No other pathological changes, including neoplasms, were considered to be related to the treatment.
将四组斯普拉格-道利大鼠每周两次肌肉注射Ferastral（一种铁-聚（山梨醇-葡萄糖酸）复合物（IPSG））或Imferon（一种铁-葡聚糖复合物），持续17周。实验持续95周。每种化合物分别给予两组，一组低剂量组和一组高剂量组。根据体重，每只大鼠的铁剂量水平分别在2.5至10毫克（25 - 50毫克/千克体重）和5至20毫克（50 - 100毫克/千克体重）之间变化。每只大鼠的铁平均总剂量经计算分别为235毫克和495毫克。另一组动物作为对照。从大约第30个实验周起，接受Ferastral和Imferon治疗的组在肌肉注射部位出现肿瘤。这些肿瘤似乎是肉瘤。在几乎所有实验开始后存活超过30周的接受治疗的动物中，肌肉注射部位都出现了肉瘤。肉瘤在高剂量组比低剂量组出现得更早，在接受Ferastral治疗的大鼠中比接受Imferon治疗的大鼠中出现得稍早。未发现其他包括肿瘤在内的病理变化与治疗有关。
