Segura J, de la Torre R, Congost M, Camí J
Institut Municipal d'Investigació Mèdica, Departament de Farmacologia i Toxicologia, Barcelona, Spain.
Clin Chem. 1989 May;35(5):879-83.
The need for external quality control for drugs-of-abuse urinalysis has long been recognized. Based on experiences in other countries, a proficiency testing program has been introduced recently in Spain. Sterile urine samples containing different concentrations of drugs and metabolites are analyzed by participating laboratories four times a year. Comprehensive educational reports reviewed by an advisory committee are released after each batch analysis. The first year's results verify (a) a beneficial influence of the program in regard to reducing errors when adequate techniques are used, (b) the need for using confirmatory techniques, and (c) the importance of experience and laboratory resources for optimizing results. The educational aspects of the program for the second year are stressing especially the in situ training of analysts and the supply of solutions of drugs and metabolites to be used as reference standards.
长期以来，人们一直认识到对滥用药物尿液分析进行外部质量控制的必要性。根据其他国家的经验，西班牙最近推出了一项能力验证计划。参与实验室每年对含有不同浓度药物和代谢物的无菌尿液样本进行四次分析。每次批次分析后都会发布由咨询委员会审核的综合教育报告。第一年的结果证实了：（a）该计划在使用适当技术时对减少误差方面的有益影响；（b）使用确证技术的必要性；以及（c）经验和实验室资源对优化结果的重要性。该计划第二年的教育重点尤其在于对分析人员的现场培训以及提供用作参考标准的药物和代谢物溶液。
