Patzakis M J, Wilkins J
Department of Orthopaedics, University of Southern California School of Medicine, Los Angeles.
Clin Orthop Relat Res. 1989 Jun(243):36-40.
Seventy-seven infections in 1104 open fracture wounds were evaluated to identify those factors that predisposed to infection. Factors could be placed into three categories: (1) increased risk, (2) no effect, and (3) inconclusive. The single most important factor in reducing the infection rate was the early administration of antibiotics that provide antibacterial activity against both gram-positive and gram-negative microorganisms. In this study, surgical debridement was performed on all open fracture wounds.
对1104例开放性骨折伤口中的77例感染进行了评估，以确定那些易导致感染的因素。这些因素可分为三类：（1）风险增加，（2）无影响，（3）不确定。降低感染率的唯一最重要因素是早期使用对革兰氏阳性和革兰氏阴性微生物均具有抗菌活性的抗生素。在本研究中，所有开放性骨折伤口均进行了手术清创。
