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重复经颅磁刺激(rTMS)对神经退行性疾病的神经保护作用:实验研究综述

The Neuroprotective Role of Repetitive Transcranial Magnetic Stimulation (rTMS) for Neurodegenerative Diseases: A Short Review on Experimental Studies.

作者信息

Yulug Burak, Hanoglu Lütfü, Kilic Ertugrul, Polat Burcu, Schabitz Wolf Rüdiger

机构信息

Istanbul-Medipol University, Department of Neurology, Istanbul, Turkey.

出版信息

Mini Rev Med Chem. 2016;16(16):1269-1273. doi: 10.2174/1389557516666160523145154.

Abstract

There are rapidly replicating human data suggesting the therapeutic and neurorestorative role of transcranial magnetic stimulation in various neurological and psychiatric disorders. However there are only limited experimental studies in the literature enlighting the neurobiological mechanisms of this technique. In the light of these findings, we aimed to review the neuroprotective effect of rTMS in various animal studies. We have shown that rTMS may exert significant neuroprotective effect through acting on the neuroinflammation, excitotoxicity, oxidative stress and Aß aggregation.

摘要

有快速更新的人体数据表明经颅磁刺激在各种神经和精神疾病中具有治疗和神经修复作用。然而,文献中仅有有限的实验研究阐明了该技术的神经生物学机制。鉴于这些发现,我们旨在综述重复经颅磁刺激在各种动物研究中的神经保护作用。我们已经表明,重复经颅磁刺激可能通过作用于神经炎症、兴奋性毒性、氧化应激和β淀粉样蛋白聚集发挥显著的神经保护作用。

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