Yulug Burak, Hanoglu Lutfu, Kilic Ertugrul
Department of Neurology, University of Istanbul-Medipol, Istanbul, Turkey; Regenerative and Restorative Medical Research Center, Experimental Neurology Laboratuary, University of Istanbul-Medipol, Istanbul, Turkey; Department of Physiology, University of Istanbul-Medipol, Istanbul, Turkey.
Department of Neurology, University of Istanbul-Medipol, Istanbul, Turkey; Regenerative and Restorative Medical Research Center, Experimental Neurology Laboratuary, University of Istanbul-Medipol, Istanbul, Turkey; Department of Physiology, University of Istanbul-Medipol, Istanbul, Turkey.
Brain Res Bull. 2017 May;131:199-206. doi: 10.1016/j.brainresbull.2017.04.015. Epub 2017 Apr 27.
Transcranial focused ultrasound (tFUS) is a novel technique that can noninvasively modulate the cortical function. Moreover, there are rapidly replicating evidence suggesting the role of tFUS for targeted neuroprotective drug delivery by increasing the permeability of the central nervous system barrier that results with increased neuroprotective activity. In contrast to the indirect neuroprotective effect, there is rare evidence suggesting the direct parenchymal neuroprotective effect of transcranial focused ultrasound (tFUS). In the light of these findings, we aimed to review the direct and indirect neuroprotective effect of FUS in various animal models of Stroke, Parkinson's Disease, Alzheimer's Disease and Major Depressive Disorder.
A literary search was conducted, utilizing search terms "animal", "focused ultrasound", "neuroprotection", "Alzheimer's Disease", "Parkinson's Disease ", "Stroke", "Neurodegenerative disease" and "Major Depressive Disorder". Items were excluded if they failed to: (1) include patients, (2) editorials, and letters.
This mini-review article presents an up-to-date review of the neuroprotective effects of tFUS in animal studies and suggests the dual neurotherapeutic role of tFUS in various neurodegenerative diseases.
Future well-conducted human studies are emergently needed to assess the neuroprotective effects of FUS.
经颅聚焦超声（tFUS）是一种能够无创调节皮质功能的新技术。此外，有迅速增加的证据表明tFUS通过增加中枢神经系统屏障的通透性来实现靶向神经保护药物递送，从而增强神经保护活性。与间接神经保护作用相反，鲜有证据表明经颅聚焦超声（tFUS）具有直接的实质神经保护作用。鉴于这些发现，我们旨在综述聚焦超声（FUS）在中风、帕金森病、阿尔茨海默病和重度抑郁症等各种动物模型中的直接和间接神经保护作用。
进行文献检索，使用搜索词“动物”“聚焦超声”“神经保护”“阿尔茨海默病”“帕金森病”“中风”“神经退行性疾病”和“重度抑郁症”。如果文章未满足以下条件则被排除：（1）纳入患者；（2）为社论和信件。
这篇小型综述文章对动物研究中tFUS的神经保护作用进行了最新综述，并提出了tFUS在各种神经退行性疾病中的双重神经治疗作用。
迫切需要未来开展精心设计的人体研究来评估FUS的神经保护作用。
