儿童中受脑型疟疾和严重疟疾贫血影响的神经认知领域。
Neurocognitive domains affected by cerebral malaria and severe malarial anemia in children.
作者信息
Bangirana Paul, Opoka Robert O, Boivin Michael J, Idro Richard, Hodges James S, John Chandy C
机构信息
Department of Psychiatry, Makerere University College of Health Sciences, Kampala, Uganda.
Department of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda.
出版信息
Learn Individ Differ. 2016 Feb;46:38-44. doi: 10.1016/j.lindif.2015.01.010. Epub 2015 Jan 16.
This study assessed the effects of cerebral malaria (CM) and severe malarial anemia (SMA) on individual neurocognitive domains. Eighty children with CM, 86 with SMA, and 61 community children (CC) were assessed for gross motor skills, fine motor skills, visual reception, receptive language, and expressive language a week after discharge (CM or SMA) or at enrolment (CC), and 6 and 12 months later. At 12-months follow-up, children with CM had significantly lower scores than CC for all outcomes. Children with SMA had significantly lower scores than CC for visual reception, receptive language, and expressive language, and scores that were lower but did not reach significance for gross and fine motor skills. Children with CM had significantly lower scores than children with SMA for fine motor skills. Children with SMA and CM have long-term impairment in multiple neurocognitive domains. Fine motor skills may be affected more profoundly in CM than SMA.
本研究评估了脑型疟疾（CM）和严重疟疾性贫血（SMA）对个体神经认知领域的影响。对80名患CM的儿童、86名患SMA的儿童和61名社区儿童（CC）在出院（CM或SMA）后一周或入组时（CC）以及6个月和12个月后进行了大运动技能、精细运动技能、视觉接受、接受性语言和表达性语言评估。在12个月随访时，患CM的儿童在所有结局指标上的得分均显著低于CC。患SMA的儿童在视觉接受、接受性语言和表达性语言方面的得分显著低于CC，在大运动和精细运动技能方面得分较低但未达到显著水平。患CM的儿童在精细运动技能方面的得分显著低于患SMA的儿童。患SMA和CM的儿童在多个神经认知领域存在长期损害。CM对精细运动技能的影响可能比对SMA更严重。
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