Denic Srdjan, Narchi Hassib, Al Mekaini Lolowa A, Al-Hammadi Suleiman, Al Jabri Omar N, Souid Abdul-Kader
Department of Medicine, College of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al-Ain, United Arab of Emirates.
Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab of Emirates.
BMC Hematol. 2016 May 21;16:15. doi: 10.1186/s12878-016-0054-8. eCollection 2016.
A high prevalence of neutropenia has been reported in several ethnic groups amongst whom many healthy individuals with low neutrophil counts undergo unnecessary investigations. This study aims to ascertain the prevalence of neutropenia (NP) in a large cohort of children from North African, Middle Eastern, and Asian countries residing in the United Arab Emirates.
Neutrophil counts of 26,542 children (one day to six years of age) from 86 countries were analyzed. The subjects were enrolled in the Well-Child-Care program of Ambulatory Health Services of Emirate of Abu Dhabi, United Arab Emirates. NP was defined as a neutrophil count <1.5 × 10(9)/L and severe NP <0.5 × 10(9)/L.
The neutrophil counts reached a nadir in the fourth week of life and changed slightly from the age of six-months to six-years. The frequency of NP was (from West-to-East): North African Arabs 15.4 %, Green Crescent Arabs 9.8 %, Peninsular Arabs 10.9 %, Iranians 3.1 %, Afghanis 2.5 %, Pakistanis 5.6 %, Indians 10.2 %, and Filipinos 7.3 %. The frequency of severe NP in North African Arabs (Sudanese) was 2.8 %, Green Crescent and Peninsular Arabs ≤1 %, Indians 1.5 %, and Filipinos 1.8 %. In 12,703 Emirati children, the frequency of NP was 10.6 % similar to their adult counterparts.
The prevalence of childhood NP varied considerably by geoethnicity. Measures to prevent the inappropriate investigations of healthy children with benign neutropenia are proposed.
据报道，在几个种族群体中，中性粒细胞减少症的患病率较高，其中许多中性粒细胞计数低的健康个体接受了不必要的检查。本研究旨在确定居住在阿拉伯联合酋长国的来自北非、中东和亚洲国家的一大群儿童中中性粒细胞减少症（NP）的患病率。
分析了来自86个国家的26542名儿童（1天至6岁）的中性粒细胞计数。这些受试者参加了阿拉伯联合酋长国阿布扎比酋长国门诊医疗服务的儿童健康保健项目。NP被定义为中性粒细胞计数<1.5×10⁹/L，严重NP<0.5×10⁹/L。
中性粒细胞计数在出生后第四周达到最低点，从6个月至6岁略有变化。NP的发生率（从西到东）：北非阿拉伯人15.4%，绿新月阿拉伯人9.8%，半岛阿拉伯人10.9%，伊朗人3.1%，阿富汗人2.5%，巴基斯坦人5.6%，印度人10.2%，菲律宾人7.3%。北非阿拉伯人（苏丹人）中严重NP的发生率为2.8%，绿新月和半岛阿拉伯人≤1%，印度人1.5%，菲律宾人1.8%。在12703名阿联酋儿童中，NP的发生率为10.6%，与成年人类似。
儿童NP的患病率因地理种族差异很大。建议采取措施防止对患有良性中性粒细胞减少症的健康儿童进行不适当的检查。
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