Reusens-Billen B, Remacle C, Hoet J J
Laboratory of Cell Biology, University of Louvain, Louvain-la-Neuve, Belgium.
Diabetes Res Clin Pract. 1989 Apr 1;6(3):213-9. doi: 10.1016/0168-8227(89)90031-4.
Diabetes during pregnancy induces specifically structural and functional changes in the fetal endocrine pancreas. Other organs are affected as well. In this study, the fetal intestinal tract which is in close connection with the endocrine pancreas was analysed during diabetic gestation. The disease was induced by two different doses of streptozotocin which led to a mild or severe diabetic state in the mother. In fetuses from mildly diabetic as well as from severely diabetic rats, the time sequence in the appearance of the differentiated cells was identical and similar to that of controls. However, morphometric analysis of the intestine of fetuses from severely diabetic rats revealed a decrease in each of the parameters measured which led to a general hypotrophy of the intestine. In the fetuses from mildly diabetic rats, the values of the morphometric parameters of the duodenal mucosa remained unchanged and comparable to those of the control group. The vascularisation of the duodenum is modified in these fetuses because the volume density of the blood vessels is significantly increased. In conclusion, both diabetic states of the mother induce various alterations in the fetal intestine, including the blood vessels. The nature of the structural changes observed in the intestine could lead to modifications in the function of the entero-pancreatic system in these fetuses.
孕期糖尿病会特异性地导致胎儿内分泌胰腺发生结构和功能变化。其他器官也会受到影响。在本研究中，对糖尿病妊娠期间与内分泌胰腺紧密相连的胎儿肠道进行了分析。通过两种不同剂量的链脲佐菌素诱导该疾病，这导致母体出现轻度或重度糖尿病状态。在轻度糖尿病大鼠和重度糖尿病大鼠的胎儿中，分化细胞出现的时间顺序相同，且与对照组相似。然而，对重度糖尿病大鼠胎儿的肠道进行形态计量学分析发现，所测量的各项参数均有所下降，导致肠道普遍萎缩。在轻度糖尿病大鼠的胎儿中，十二指肠黏膜的形态计量学参数值保持不变，与对照组相当。这些胎儿十二指肠的血管形成发生了改变，因为血管的体积密度显著增加。总之，母体的两种糖尿病状态都会导致胎儿肠道包括血管发生各种改变。在肠道中观察到的结构变化的性质可能会导致这些胎儿的肠胰系统功能发生改变。
