基于MUC1糖肽的多组分自组装抗肿瘤纳米疫苗。
Multi-component self-assembled anti-tumor nano-vaccines based on MUC1 glycopeptides.
作者信息
Sun Z Y, Chen P G, Liu Y F, Zhang B D, Wu J J, Chen Y X, Zhao Y F, Li Y M
机构信息
Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P.R. China.
出版信息
Chem Commun (Camb). 2016 Jun 18;52(48):7572-5. doi: 10.1039/c6cc02000c. Epub 2016 May 24.
PMID:27216415
Abstract
Novel multi-component self-assembled nano-vaccines containing both Pam3CSK4 and CpG were developed for the first time. These multi-component vaccines could effectively activate the macrophages in vitro and elicit strong antibody immune responses and anti-tumor immune responses in vivo.
摘要
首次开发出了同时包含Pam3CSK4和CpG的新型多组分自组装纳米疫苗。这些多组分疫苗能够在体外有效激活巨噬细胞，并在体内引发强烈的抗体免疫反应和抗肿瘤免疫反应。
Zotero 插件