Powder Technology Laboratory, Ecole Polytechnique Federale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
Inserm, U1148, Laboratory for Vascular Translational Science, UFR SMBH, Université Paris 13, Sorbonne Paris Cité, F-93017 Bobigny, France.
Biochim Biophys Acta Gen Subj. 2017 Jan;1861(1 Pt B):3621-3626. doi: 10.1016/j.bbagen.2016.05.016. Epub 2016 May 20.
We investigate the effect of several coatings applied in biomedical applications to iron oxide nanoparticles on the size, structure and composition of the particles. The four structural techniques employed - TEM, DLS, VSM, SAXS and EXAFS - show no significant effects of the coatings on the spherical shape of the bare nanoparticles, the average sizes or the local order around the Fe atoms. The NPs coated with hydroxylmethylene bisphosphonate or catechol have a lower proportion of magnetite than the bare and citrated ones, raising the question whether the former are responsible for increasing the valence state of the oxide on the NP surfaces and lowering the overall proportion of magnetite in the particles. VSM measurements show that these two coatings lead to a slightly higher saturation magnetization than the citrate. This article is part of a Special Issue entitled "Science for Life" Guest Editor: Dr. Austen Angell, Dr. Salvatore Magazù and Dr. Federica Migliardo.
我们研究了几种应用于氧化铁纳米粒子的生物医学涂层对粒子尺寸、结构和组成的影响。所采用的四种结构技术——TEM、DLS、VSM、SAXS 和 EXAFS——均表明涂层对裸露纳米粒子的球形形状、平均尺寸或 Fe 原子周围的局部有序性没有显著影响。与裸露的和柠檬酸根修饰的纳米粒子相比，用羟亚甲基二膦酸盐或儿茶酚修饰的 NPs 中磁铁矿的比例较低，这就提出了一个问题，即前者是否负责增加 NP 表面氧化物的价态，并降低颗粒中磁铁矿的总体比例。VSM 测量表明，这两种涂层导致的饱和磁化强度略高于柠檬酸根。本文是题为“科学为生命服务”的特刊的一部分，客座编辑：Austen Angell 博士、Salvatore Magazù 博士和 Federica Migliardo 博士。
