银屑病中的乙酰化酶表型。

Acetylator phenotype in psoriasis.

作者信息

Jiménez-Nieto L C, Ladero J M, Fernández-Gundín M J, Robledo A

机构信息

Department of Medicine, Hospital Universitario San Carlos, Universidad Complutense, Madrid, Spain.

出版信息

Dermatologica. 1989;178(3):136-7. doi: 10.1159/000248411.

DOI:10.1159/000248411

PMID:2721804

Abstract

Acetylator phenotype has been determined with sulfamethazine in 64 psoriatic patients and in 157 normal control subjects. Forty patients (62.5%) versus 90 control subjects (57.3%) were slow acetylators (p = NS). However, 81% of the 27 patients with psoriatic siblings were slow acetylators (p less than 0.05). Slow acetylator phenotype may be a genetic risk factor for the development of psoriasis.

摘要

已用磺胺二甲嘧啶对64例银屑病患者和157名正常对照者测定了乙酰化代谢表型。40例患者（62.5%）为慢乙酰化代谢者，而90名对照者（57.3%）为慢乙酰化代谢者（p=无显著性差异）。然而，在27例有银屑病亲属的患者中，81%为慢乙酰化代谢者（p<0.05）。慢乙酰化代谢表型可能是银屑病发病的一个遗传危险因素。