Department of Biochemistry, Division of Chemistry, UT Southwestern Medical Center , 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, United States.
Org Lett. 2016 Jun 3;18(11):2608-11. doi: 10.1021/acs.orglett.6b01104. Epub 2016 May 24.
A novel [3 + 2]-cycloaddition between azomethine imines and lithium ynolates is described to synthesize bicyclic pyrazolidinones. These bicyclic pyrazolidinones are versatile intermediates to form β-amino acids and monocyclic pyrazolidinones. High diastereoselectivity and stereospecificity allow access to optically active products.
描述了一种新型的[3 + 2]-环加成反应,即亚胺基和锂烯醇盐之间的反应,用于合成双环吡唑烷酮。这些双环吡唑烷酮是合成β-氨基酸和单环吡唑烷酮的多功能中间体。高的非对映选择性和立体特异性允许获得光学活性产物。