N-杂环卡宾催化α-氯代醛与甲亚胺亚胺的[2+3]环缩合反应。
N-Heterocyclic carbene-catalyzed [2+3] cyclocondensation of α-chloroaldehydes with azomethine imines.
作者信息
Gao Zhong-Hua, Chen Xiang-Yu, Cheng Jin-Tang, Liao Wei-Lin, Ye Song
机构信息
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Chem Commun (Camb). 2015 Jun 7;51(45):9328-31. doi: 10.1039/c5cc01238d.
PMID:25959721
Abstract
An N-heterocyclic carbene-catalyzed enantioselective [2+3] cyclocondensation of α-chloroaldehydes with azomethine imines was developed. The corresponding pyrazolidinones were obtained in good yields with moderate to good diastereoselectivities and excellent enantioselectivities.
摘要
开发了一种N-杂环卡宾催化的α-氯代醛与甲亚胺亚胺的对映选择性[2+3]环缩合反应。以良好的产率、中等至良好的非对映选择性和优异的对映选择性得到了相应的吡唑烷酮。
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