Hämäläinen Riikka H
Department of Neurobiology, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Curr Opin Genet Dev. 2016 Jun;38:83-89. doi: 10.1016/j.gde.2016.04.008. Epub 2016 May 21.
Stem cells require tight control of energy metabolism to maintain homeostasis. They possess few immature mitochondria, repress mitochondrial respiration and instead use glycolysis to produce energy, yet mitochondrial defects can lead to severe stem cell dysfunction. Recent studies have shown that mitochondrial mass, function and integrity are tightly controlled in stem cells and the integrity of the mitochondrial genome is equally important to nuclear genome integrity for proper stem cell homeostasis. Mitochondria are now considered central in regulating stem cell function and governing cellular fate choices. This review will summarize recent advances highlighting the importance of mitochondrial integrity in stem cells.
干细胞需要严格控制能量代谢以维持体内平衡。它们拥有少量未成熟的线粒体，抑制线粒体呼吸，转而利用糖酵解来产生能量，然而线粒体缺陷会导致严重的干细胞功能障碍。最近的研究表明，干细胞中线粒体的质量、功能和完整性受到严格控制，并且线粒体基因组的完整性对于维持适当的干细胞体内平衡而言，与核基因组完整性同样重要。如今，线粒体被认为在调节干细胞功能和决定细胞命运选择方面起着核心作用。本综述将总结近期的进展，强调线粒体完整性在干细胞中的重要性。
