线粒体在干细胞命运和衰老中的作用。
The role of mitochondria in stem cell fate and aging.
机构信息
Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun-Yat Sen University, 510080, Guangzhou, China.
Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, CH-1015, Switzerland.
出版信息
Development. 2018 Apr 13;145(8):dev143420. doi: 10.1242/dev.143420.
The importance of mitochondria in energy metabolism, signal transduction and aging in post-mitotic tissues has been well established. Recently, the crucial role of mitochondrial-linked signaling in stem cell function has come to light and the importance of mitochondria in mediating stem cell activity is becoming increasingly recognized. Despite the fact that many stem cells exhibit low mitochondrial content and a reliance on mitochondrial-independent glycolytic metabolism for energy, accumulating evidence has implicated the importance of mitochondrial function in stem cell activation, fate decisions and defense against senescence. In this Review, we discuss the recent advances that link mitochondrial metabolism, homeostasis, stress responses, and dynamics to stem cell function, particularly in the context of disease and aging. This Review will also highlight some recent progress in mitochondrial therapeutics that may present attractive strategies for improving stem cell function as a basis for regenerative medicine and healthy aging.
线粒体在能量代谢、信号转导和有丝分裂后组织的衰老中的重要性已得到充分证实。最近，线粒体相关信号在干细胞功能中的关键作用已经显现出来，线粒体在介导干细胞活性方面的重要性也越来越受到人们的认可。尽管许多干细胞表现出低线粒体含量，并依赖于线粒体非依赖性糖酵解代谢来获取能量，但越来越多的证据表明线粒体功能对于干细胞的激活、命运决定和抵御衰老至关重要。在这篇综述中，我们讨论了将线粒体代谢、动态平衡、应激反应联系起来的最新进展与干细胞功能之间的关系，特别是在疾病和衰老的背景下。这篇综述还将重点介绍线粒体治疗的一些最新进展，这些进展可能为改善干细胞功能提供有吸引力的策略，作为再生医学和健康衰老的基础。
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