Kulisić Sandra Marinović
Acta Med Croatica. 2016 Mar;70(1):5-17.
Lower leg ulcer is the most common form of ulceration of lower extremities. The prevalence of leg ulcer varies among studies from 0.1% to 0.6%. During the last decade, new concepts on the inflammatory phase in chronic ulcer have been discovered, such as the importance of metalloproteinases, growth factor, irregular muscular function, vascular insufficiency and presence of biofilm in the ulcer that prevents healing. There are several hypotheses to explain the pathophysiological steps, referring to popliteal venous hypertension. Currently, the treatment of leg ulcer relies on due knowledge of ulcer pathophysiology and making an accurate diagnosis. Today, modern supportive dressings improve the patient's quality of life; however, their targeted application according to the protocol and indications is required. A new method of efficient wound biofim exclusion today is the application of hydrofiber dressings containing a combination of silver ions and two disinfectants because they influence the exclusion and prevention of new biofilm formation in the ulcer.
小腿溃疡是下肢溃疡最常见的形式。不同研究中腿部溃疡的患病率在0.1%至0.6%之间。在过去十年中，人们发现了慢性溃疡炎症期的新概念，如金属蛋白酶、生长因子、不规则肌肉功能、血管功能不全以及溃疡中生物膜的存在对愈合的影响。有几种假说来解释涉及腘静脉高压的病理生理步骤。目前，腿部溃疡的治疗依赖于对溃疡病理生理学的充分了解和准确诊断。如今，现代支持性敷料改善了患者的生活质量；然而，需要根据方案和适应证有针对性地应用。如今一种有效排除伤口生物膜的新方法是应用含有银离子和两种消毒剂组合的水凝胶敷料，因为它们有助于排除并预防溃疡中新生物膜的形成。
