Kanmura Shuji, Hamamoto Hitomi, Morinaga Yuko, Oda Kohei, Fujita Toshihiro, Arima Shiho, Nasu Yuichiro, Sasaki Fumisato, Hashimoto Shinichi, Taguchi Hiroki, Setoyama Hitoshi, Ido Akio
Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Digestion. 2016;93(4):300-8. doi: 10.1159/000446210. Epub 2016 May 26.
BACKGROUND/AIM: Fecal markers have recently been found to provide convenient and noninvasive assessment of intestinal inflammation in inflammatory bowel disease (IBD). In this study, we examined the clinical significance of fecal human neutrophil peptides (F-HNP) in the evaluation of IBD disease activity.
This study enrolled 70 patients with IBD, consisting of 45 patients with ulcerative colitis (UC), 25 patients with Crohn's disease (CD), and 11 non-IBD controls. Stools samples were evaluated for the association between F-HNP concentration and disease and endoscopic activity in each group and the correlation between F-HNP and fecal calprotectin (F-CP) concentrations.
Median F-HNP levels were as follows: UC: 25.6 ng/ml; CD: 20.1 ng/ml; and non-IBD controls: 4.9 ng/ml. F-HNP levels were significantly higher in each IBD group, especially in the UC group, than in the control group. In the UC group, both F-HNP and F-CP levels were significantly higher during active disease compared to the remission phase. Both markers were significantly correlated with the Mayo endoscopic score, although the correlation was stronger for F-HNP than for F-CP (r = 0.66 vs. r = 0.54).
F-HNP is a noninvasive marker that is useful for evaluating UC endoscopic activity.
背景/目的：最近发现粪便标志物可为炎症性肠病（IBD）的肠道炎症提供便捷且无创的评估。在本研究中，我们检测了粪便人中性粒细胞肽（F-HNP）在评估IBD疾病活动中的临床意义。
本研究纳入了70例IBD患者，其中包括45例溃疡性结肠炎（UC）患者、25例克罗恩病（CD）患者以及11例非IBD对照。对粪便样本进行评估，以分析每组中F-HNP浓度与疾病及内镜活动之间的关联，以及F-HNP与粪便钙卫蛋白（F-CP）浓度之间的相关性。
F-HNP水平中位数如下：UC组为25.6 ng/ml；CD组为20.1 ng/ml；非IBD对照组为4.9 ng/ml。各IBD组的F-HNP水平均显著高于对照组，尤其是UC组。在UC组中，与缓解期相比，活动期的F-HNP和F-CP水平均显著更高。两种标志物均与梅奥内镜评分显著相关，尽管F-HNP的相关性强于F-CP（r = 0.66对r = 0.54）。
F-HNP是一种无创标志物，可用于评估UC的内镜活动。
