von der Höh N H, Völker A, Jeszenszky D, Heyde C-E
Klinik und Poliklinik für Orthopädie, Unfallchirurgie und plastische Chirurgie, Universitätsklinikum Leipzig AöR, Liebigstrasse 18, 04103, Leipzig, Deutschland.
Wirbelsäulenchirurgie, Muskulo-Skelettal Zentrum, Schulthess Klinik, Lengghalde 2, 8008, Zürich, Schweiz.
Orthopade. 2016 Jun;45(6):484-90. doi: 10.1007/s00132-016-3271-8.
Chronic non-bacterial osteomyelitis (CNO) in childhood and adolescence is a non-infectious autoinflammatory disease of the bone with partial involvement of adjacent joints and soft tissue. The etiology is unknown. The disease can occur singular or recurrent. Individual bones can be affected and multiple lesions can occur. Chronic recurrent multifocal osteomyelitis (CRMO) shows the whole picture of CNO. Accompanying but temporally independent of the bouts of osteomyelitis, some patients show manifestations in the skin, eyes, lungs and the gastrointestinal tract. The article gives an overview of the clinical manifestations, diagnostic procedures, and treatment options for CRMO involvement of the spine based on the current literature and our own cases.
儿童和青少年慢性非细菌性骨髓炎（CNO）是一种骨骼的非感染性自身炎症性疾病，相邻关节和软组织部分受累。病因不明。该疾病可单发或复发。可累及单个骨骼，也可出现多个病灶。慢性复发性多灶性骨髓炎（CRMO）呈现出CNO的全貌。部分患者在骨髓炎发作时伴有但在时间上独立于皮肤、眼睛、肺部和胃肠道的表现。本文基于当前文献和我们自己的病例，对CRMO累及脊柱的临床表现、诊断方法和治疗选择进行综述。
