Singer G, Willis G L
Brain Res Bull. 1977 Nov-Dec;2(6):485-9. doi: 10.1016/0361-9230(77)90057-0.
The lateral hypothalamic (LH) syndrome characterized by impairment of the ability to regulate food and water intake has been reported to occur after injections of 6-hydroxydopamine (6-OHDA) into this region. In the present experiment the fluorescence histochemical technique was used to assess monoamine depletion of noradrenaline and dopamine containing neurons following intrahypothalamic injection of 6-OHDA. Results show that the intensity and area of monoamine accumulation in axons served by 6-OHDA is correlated with the severity of behavioral deficits but that actual catecholamine depletion of either the corpus striatum or the hypothalamus is unrelated to the syndrome. Possible mechanisms of action of this accumulation in producing behavioral deficits are discussed.
据报道，向外侧下丘脑（LH）区域注射6-羟基多巴胺（6-OHDA）后会出现以调节食物和水摄入能力受损为特征的外侧下丘脑综合征。在本实验中，采用荧光组织化学技术评估下丘脑内注射6-OHDA后去甲肾上腺素能和多巴胺能神经元的单胺耗竭情况。结果表明，由6-OHDA供应轴突的单胺积累强度和面积与行为缺陷的严重程度相关，但纹状体或下丘脑的实际儿茶酚胺耗竭与该综合征无关。讨论了这种积累产生行为缺陷的可能作用机制。
