Leibowitz S F
Appetite. 1984 Sep;5(3):268-71. doi: 10.1016/s0195-6663(84)80022-7.
6-Hydroxydopamine (6-OHDA) injection into the rat hypothalamus produces profound changes in eating behavior and body weight gain. Willis and Smith have demonstrated an anorexic effect of lateral hypothalamic (LH) 6-OHDA, which they correlate with local catecholamine release from degenerating axons just behind the lesion. Work from our own laboratory has recently demonstrated that 6-OHDA injection into the medial paraventricular nucleus (PVN) has an initial effect of stimulating daily food intake and body weight gain. It is suggested that this phenomenon, consistent with reports of enhanced eating with PVN injection of norepinephrine (NE), is due to 6-OHDA-induced release of endogenous NE. Subsequently, PVN 6-OHDA causes hypophagia and reduced body weight. Although histochemical and biochemical analyses reveal a 60-90% decrease in PVN norepinephrine and dopamine after 6-OHDA treatment, a close association between the precise degree of catecholamine loss and magnitude of behavioral response could not be detected.
向大鼠下丘脑注射6-羟基多巴胺（6-OHDA）会使进食行为和体重增加产生显著变化。威利斯和史密斯证明了下丘脑外侧区（LH）注射6-OHDA具有厌食作用，他们将此与损伤部位后方退化轴突释放的局部儿茶酚胺联系起来。我们自己实验室最近的研究表明，向室旁核内侧（PVN）注射6-OHDA最初会刺激每日食物摄入量和体重增加。有人认为，这一现象与室旁核注射去甲肾上腺素（NE）后进食增加的报道一致，是由于6-OHDA诱导内源性NE释放所致。随后，PVN注射6-OHDA会导致摄食减少和体重减轻。尽管组织化学和生化分析显示，6-OHDA处理后PVN中的去甲肾上腺素和多巴胺减少了60-90%，但未检测到儿茶酚胺损失的精确程度与行为反应幅度之间的密切关联。
