Department of Food and Nutrition, Hanyang University , 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Republic of Korea.
Department of Food Science and Technology, Sejong University , 98 Gunja-dong, Gwangjin-gu, Seoul 143-747, Republic of Korea.
J Agric Food Chem. 2016 Jul 6;64(26):5384-8. doi: 10.1021/acs.jafc.6b00849. Epub 2016 Jun 23.
The aim of this study was to formulate buccal mucoadhesive nanoparticles (NPs) using the natural mucoadhesive polymers. The natural mucoadhesive polymers chitosan (CS) and dextran sulfate sodium salt (DS) were used to prepare mucoadhesive NPs using the ionic gelation method. As the molecular weight of DS decreased, the amount of mucin and the number of buccal cells adsorbed on DS increased. The CS/DS NPs ranged from 100 to 200 nm in diameter. The adhesive interactions of CS/DS NPs with mucin were not significantly different from those of CS/sodium triphosphate pentabasic (TPP) NPs; however, CS/DS NPs exhibited 5 times greater mucoadhesive activity to buccal cells compared to control CS/TPP NPs in ex vivo adhesion tests. These results indicate that the buccal mucoadhesive properties of NPs can be improved using natural mucoadhesive polymers.
本研究旨在通过使用天然的黏膜黏附聚合物来制备口腔黏膜黏附纳米粒子（NPs）。使用壳聚糖（CS）和硫酸葡聚糖钠盐（DS）这两种天然黏膜黏附聚合物，通过离子凝胶化法制备黏膜黏附 NPs。随着 DS 分子量的降低，吸附在 DS 上的黏蛋白和口腔细胞的数量增加。CS/DS NPs 的直径在 100 到 200nm 之间。CS/DS NPs 与黏蛋白的黏附相互作用与 CS/三聚磷酸钠五水合物（TPP）NPs 没有显著差异；然而，与对照 CS/TPP NPs 相比，CS/DS NPs 在离体黏附试验中对口腔细胞表现出 5 倍更强的黏膜黏附活性。这些结果表明，使用天然的黏膜黏附聚合物可以改善 NPs 的口腔黏膜黏附性能。
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