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硒化壳聚糖硫酸酯对肝细胞和无特定病原体鸡的谷胱甘肽系统的影响。

Effects of selenide chitosan sulfate on glutathione system in hepatocytes and specific pathogen-free chickens.

机构信息

Institute of Animal Nutritional Metabolic Disease and Poisoning Disease, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, 266109, China.

Department of Animal Science, University of Manitoba, Winnipeg Manitoba, R3T 2N2, Canada.

出版信息

Poult Sci. 2020 Aug;99(8):3979-3986. doi: 10.1016/j.psj.2020.04.024. Epub 2020 May 26.

DOI:10.1016/j.psj.2020.04.024
PMID:32731985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7597923/
Abstract

This study aimed to investigate the effects of selenide chitosan sulfate (Se-CTS-S) on glutathione (GSH) system in hepatocytes and chickens. Chitosan, sodium selenite (NaSeO), selenide chitosan, chitosan sulfate (CTS-S), and Se-CTS-S were added to the culture medium and the basal diets; glutathione peroxidase (GSH-Px) activity, GSH content, total antioxidant capacity (T-AOC), and mRNA levels of cellular GPx (GPx-1) and phospholipid hydroperoxide GPx (GPx-4) in vivo and in vitro were determined. The results showed that Se-CTS-S increased (P < 0.05) GPx-1 and GPx-4 mRNA levels in hepatocytes and livers, and GSH-Px activity, GSH content, and T-AOC in the medium, hepatocytes, plasma, and livers compared with the control and chitosan treatments. Compared with CTS-S, Se-CTS-S treatments increased (P < 0.05) GPx-1 and GPx-4 mRNA levels in hepatocytes and livers, and GSH-Px activity, GSH content, and T-AOC capacity in the medium, hepatocytes, and livers. Compared with NaSeO and CTS-Se, Se-CTS-S increased (P < 0.05) GPx-1 mRNA levels in hepatocytes and livers, GPx-4 mRNA levels in hepatocytes and livers, GSH-Px activity in the medium, hepatocytes, and livers, GSH contents in plasma and livers, and T-AOC in the medium, plasma, and livers. Thus, Se-CTS-S showed better biological activity that mainly benefited from the synergistic effects of Se and sulfate on GSH system.

摘要

本研究旨在探讨硒代壳聚糖硫酸酯（Se-CTS-S）对肝细胞和鸡的谷胱甘肽（GSH）系统的影响。壳聚糖、亚硒酸钠（NaSeO）、硒代壳聚糖、壳聚糖硫酸酯（CTS-S）和 Se-CTS-S 被添加到培养基和基础日粮中；体内和体外测定了谷胱甘肽过氧化物酶（GSH-Px）活性、GSH 含量、总抗氧化能力（T-AOC）以及细胞 GPx（GPx-1）和磷脂氢过氧化物 GPx（GPx-4）的 mRNA 水平。结果表明，与对照组和壳聚糖处理组相比，Se-CTS-S 增加了肝细胞和肝脏中 GPx-1 和 GPx-4 mRNA 水平以及培养基、肝细胞、血浆和肝脏中的 GSH-Px 活性、GSH 含量和 T-AOC。与 CTS-S 相比，Se-CTS-S 增加了肝细胞和肝脏中 GPx-1 和 GPx-4 mRNA 水平以及培养基、肝细胞和肝脏中的 GSH-Px 活性、GSH 含量和 T-AOC。与 NaSeO 和 CTS-Se 相比，Se-CTS-S 增加了肝细胞和肝脏中 GPx-1 mRNA 水平、肝细胞和肝脏中 GPx-4 mRNA 水平、培养基、肝细胞和肝脏中的 GSH-Px 活性、血浆和肝脏中的 GSH 含量以及培养基、血浆和肝脏中的 T-AOC。因此，Se-CTS-S 表现出更好的生物学活性，这主要得益于 Se 和硫酸盐对 GSH 系统的协同作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d20/7597923/eaadcd0052c3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d20/7597923/70d66006e494/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d20/7597923/463fd01db08b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d20/7597923/7734cd8b4e29/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d20/7597923/eaadcd0052c3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d20/7597923/70d66006e494/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d20/7597923/463fd01db08b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d20/7597923/7734cd8b4e29/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d20/7597923/eaadcd0052c3/gr4.jpg

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