Kartha Ganesh K, Sanfrancesco Joseph, Udoji Esther, Chaparala Hemant, Hansel Donna, Jones J Stephen
Glickman Urological & Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH.
Department of Pathology, Cleveland Clinic Foundation, Cleveland, OH.
Rev Urol. 2015;17(2):106-9. doi: 10.3909/riu0643.
A 59-year-old man was diagnosed with urothelial carcinoma involving an isolated cerebellar metastasis after presenting to the emergency department for headache complaints. After selective surgical excision of the symptomatic brain lesion and delayed cystectomy due to intractable hematuria, he survived 11 years without evidence of recurrence or subsequent systemic chemotherapy. He eventually expired after delayed recurrence in the lung, supraclavicular lymph node, and brain. To our knowledge, this is the only case of prolonged survival from urothelial carcinoma after selective surgical extirpation of the primary and metastatic lesion without subsequent systemic chemotherapy.
一名59岁男性因头痛前往急诊科就诊,被诊断为尿路上皮癌伴孤立性小脑转移。在对有症状的脑病灶进行选择性手术切除以及因顽固性血尿进行延迟性膀胱切除术后,他存活了11年,无复发迹象,也未接受后续全身化疗。他最终在肺部、锁骨上淋巴结和脑部出现延迟复发后死亡。据我们所知,这是唯一一例在选择性手术切除原发灶和转移灶后未进行后续全身化疗而长期存活的尿路上皮癌病例。