Gonzalez Andres, Moya-Alvarado Guillermo, Gonzalez-Billaut Christian, Bronfman Francisca C
MINREB and Center for Ageing and Regeneration (CARE UC), Faculty of Biological Sciences, Department of Physiology, Pontificia Universidad Católica de Chile, Santiago, Chile.
Laboratory of Cell and Neuronal Dynamics, Department of Biology, Faculty of Sciences, Universidad de Chile and Geroscience Center for Brain Health and Metabolism, Santiago, Chile.
Cytoskeleton (Hoboken). 2016 Oct;73(10):612-628. doi: 10.1002/cm.21312. Epub 2016 Jun 13.
Brain-derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms underlying this process are not fully understood. In recent years, several advances have shed new light on the processes behind the regulation of BDNF-mediated structural plasticity including control of neuronal transcription, local translation of proteins, and regulation of cytoskeleton and membrane dynamics. In this review, we summarize recent advances in the field of BDNF signaling in neurons to induce neuronal growth. © 2016 Wiley Periodicals, Inc.
脑源性神经营养因子（BDNF）及其受体TrkB和p75在成熟神经系统的发育和维持过程中调节树突和轴突的生长；然而，这一过程背后的细胞和分子机制尚未完全明确。近年来，多项进展为BDNF介导的结构可塑性调节过程背后的机制带来了新的认识，包括对神经元转录的控制、蛋白质的局部翻译以及细胞骨架和膜动力学的调节。在本综述中，我们总结了神经元中BDNF信号传导领域诱导神经元生长的最新进展。© 2016威利期刊公司。
