氢氧化钙、氯己定和生物活性玻璃基根管治疗药物的离子释放与pH值
Ions Release and pH of Calcium Hydroxide-, Chlorhexidine- and Bioactive Glass-Based Endodontic Medicaments.
作者信息
Carvalho Ceci Nunes, Freire Laila Gonzales, Carvalho Alexandre Pinheiro Lima de, Duarte Marco Antonio Húngaro, Bauer José, Gavini Giulio
机构信息
Department of Restorative Dentistry, Dental School, UNICEUMA - Universidade Ceuma, São Luis, MA, Brazil, Centro Universitário do Maranhão, Dental School, Universidade Ceuma, São Luis MA , Brazil.
Department of Restorative Dentistry, Dental School, USP - Universidade de São Paulo, São Paulo, SP, Brazil, Universidade de São Paulo, Department of Restorative Dentistry, Dental School, Universidade de São Paulo, São Paulo SP , Brazil.
出版信息
Braz Dent J. 2016 May-Jun;27(3):325-31. doi: 10.1590/0103-6440201600602.
This study evaluated pH and release of calcium, sodium and phosphate ions from different medications in human dentin. Fifty premolars were prepared and randomly divided into groups: (CHX) - 2% chlorhexidine gel; (CHX + CH) - CHX + calcium hydroxide PA; (CH) - CH + propylene glycol 600; (NPBG) - experimental niobium phosphate bioactive glass + distilled water; (BG) - bioactive glass (Bio-Gran) + distilled water. The specimens were immersed in deionized water and the pH variations were measured. The quantification of ions in the solutions was made by inductively coupled plasma - atomic emission spectroscopy (ICP/AES) at 10 min, 24 h, 7, 14, 21 and 30 days. The results were analyzed by ANOVA and Tukey`s test, with a significance level of 5%. CH had the highest level of calcium ions release at 30 days, while CHX and BG released more sodium ions. BG, NPBG and CHX released a higher amount of phosphate ions. The pH of CH was significantly higher compared with the other groups. CH favored the greatest increase of pH and calcium ions release. The bioactive glasses released more sodium and phosphate ions and presented an alkaline pH immediately and after 30 days.
本研究评估了不同药物在人牙本质中pH值以及钙、钠和磷酸根离子的释放情况。制备了50颗前磨牙并随机分为几组：（CHX）——2%洗必泰凝胶；（CHX + CH）——洗必泰 + 氢氧化钙PA；（CH）——氢氧化钙 + 600丙二醇；（NPBG）——实验性铌磷酸盐生物活性玻璃 + 蒸馏水；（BG）——生物活性玻璃（Bio - Gran）+ 蒸馏水。将标本浸入去离子水中并测量pH值变化。在10分钟、24小时、7天、14天、21天和30天时，通过电感耦合等离子体 - 原子发射光谱法（ICP/AES）对溶液中的离子进行定量分析。结果采用方差分析和Tukey检验进行分析，显著性水平为5%。在30天时，CH的钙离子释放量最高，而洗必泰（CHX）和生物活性玻璃（BG）释放的钠离子更多。生物活性玻璃（BG）、实验性铌磷酸盐生物活性玻璃（NPBG）和洗必泰（CHX）释放的磷酸根离子量更高。与其他组相比，CH的pH值显著更高。CH有利于pH值和钙离子释放的最大增加。生物活性玻璃释放出更多的钠和磷酸根离子，并且在即刻和30天后呈现碱性pH值。
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