Jacinto Rogério Castilho, Linhares-Farina Giane, Sposito Otávio da Silva, Zanchi César Henrique, Cenci Maximiliano Sérgio
Endodontic Division, Dental School, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Department of Semiology and Clinics, Dental School, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Braz Oral Res. 2015;29. doi: 10.1590/1807-3107BOR-2015.vol29.0036. Epub 2015 Feb 11.
The addition of chlorhexidine (CHX) to a resinous experimental Mineral Trioxide Aggregate (E-MTA) based root-end filling material is an alternative to boost its antimicrobial activity. However, the influence of chlorhexidine on the properties of this material is unclear. The aim of this study was to evaluate the influence of 2% chlorhexidine on the pH, calcium ion release and setting time of a Bisphenol A Ethoxylate Dimethacrylate/Mineral Trioxide Aggregate (Bis-EMA/MTA) based dual-cure experimental root-end filling material (E-MTA), in comparison with E-MTA without the addition of CHX and with conventional white MTA (W-MTA). The materials were placed in polyethylene tubes, and immersed in deionized water to determine pH (digital pH meter) and calcium ion release (atomic absorption spectrometry technique). The setting time of each material was analyzed using Gilmore needles. The data were statistically analyzed at a significance level of 5%. E-MTA + CHX showed an alkaline pH in the 3 h period of evaluation, the alkalinity of which decreased but remained as such for 15 days. The pH of E-MTA + CHX was higher than the other two materials after 7 days, and lower after 30 days (p < 0.05). All of the materials were found to release calcium ions throughout the 30 days of the study. The addition of CHX increased the calcium ion release of E-MTA to levels statistically similar to W-MTA. E-MTA showed shorter initial and final setting time, compared with W-MTA (p < 0.05). The addition of 2% CHX to MTA prevented setting of the material. The addition of CHX to E-MTA increased its pH and calcium ion release. However, it also prevented setting of the material.
在基于树脂的实验性三氧化矿物凝聚体（E-MTA）根充材料中添加洗必泰（CHX）是增强其抗菌活性的一种替代方法。然而，洗必泰对该材料性能的影响尚不清楚。本研究的目的是评估2%洗必泰对双酚A乙氧基二甲基丙烯酸酯/三氧化矿物凝聚体（Bis-EMA/MTA）基双固化实验性根充材料（E-MTA）的pH值、钙离子释放和凝固时间的影响，并与未添加CHX的E-MTA和传统白色MTA（W-MTA）进行比较。将材料置于聚乙烯管中，浸入去离子水中以测定pH值（数字pH计）和钙离子释放（原子吸收光谱技术）。使用吉尔摩针分析每种材料的凝固时间。数据在5%的显著性水平上进行统计学分析。E-MTA + CHX在评估的3小时内显示出碱性pH值，其碱度降低但在15天内仍保持碱性。7天后，E-MTA + CHX的pH值高于其他两种材料，30天后则较低（p < 0.05）。在研究的30天内，所有材料均释放钙离子。添加CHX使E-MTA的钙离子释放增加至与W-MTA统计学上相似的水平。与W-MTA相比，E-MTA的初始和最终凝固时间更短（p < 0.05）。向MTA中添加2% CHX会阻止材料凝固。向E-MTA中添加CHX会增加其pH值和钙离子释放。然而，这也会阻止材料凝固。
