Willard M D, Bailey M Q, Hauptman J, Mullaney T
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824.
J Am Vet Med Assoc. 1989 May 15;194(10):1449-51.
A young adult Doberman Pinscher had clinical signs and laboratory data consistent with the copper-associated hepatopathy commonly found in Doberman Pinschers. Hepatic biopsy and hepatic copper analysis did not support this diagnosis. Furthermore, changes seen in the hepatic biopsy specimen did not explain the acquired portosystemic shunting or the portal hypertension that the dog had. A mesentery venoportagram revealed markedly delayed filling of one portal vein, and necropsy revealed a small thrombus partially occluding that hepatic vein. It was not determined whether obstructed portal venous flow caused the portal vein thrombus or vice versa; however, it was theorized that the portal vein thrombus, once formed, contributed to further portal hypertension and/or delayed portal vein filling.
一只年轻的成年杜宾犬出现了与杜宾犬常见的铜相关肝病相符的临床症状和实验室数据。肝活检和肝铜分析不支持这一诊断。此外，肝活检标本中所见的变化无法解释该犬所患的后天性门体分流或门静脉高压。肠系膜静脉造影显示一条门静脉充盈明显延迟，尸检发现一个小血栓部分阻塞了该肝静脉。尚无法确定是阻塞的门静脉血流导致了门静脉血栓形成，还是反之；然而，据推测，门静脉血栓一旦形成，会导致进一步的门静脉高压和/或门静脉充盈延迟。
