Grøndahl Camilla, Rittig Søren, Povlsen Johan Vestergaard, Kamperis Kostantinos
Department of Pediatrics, Aarhus University Hospital, Skejby, Aarhus, Denmark.
Department of Renal Medicine, Aarhus University Hospital, Skejby, Aarhus, Denmark.
Case Rep Nephrol Dial. 2016 Apr 14;6(1):70-5. doi: 10.1159/000445678. eCollection 2016 Jan-Apr.
Acute postinfectious glomerulonephritis (PIGN) affects children typically after upper respiratory tract or skin infections with streptococci but can complicate the course of other infections. In children, it is generally a self-limiting disease with excellent prognosis. This paper reports a previously healthy 4-year-old boy who experienced a protracted course of PIGN with persisting episodes of gross haematuria, proteinuria, decreased complement C3c levels but normal P-creatinine levels. Due to the protracted course and the nephrotic-range proteinuria, a renal biopsy was performed 6 months after the initial presentation and the overall pathology was consistent with acute endocapillary glomerulonephritis.
急性感染后肾小球肾炎(PIGN)通常在儿童上呼吸道或皮肤感染链球菌后发病,但也可能使其他感染的病程复杂化。在儿童中,它一般是一种自限性疾病,预后良好。本文报告了一名此前健康的4岁男孩,他经历了迁延不愈的PIGN病程,持续出现肉眼血尿、蛋白尿,补体C3c水平降低,但血肌酐水平正常。由于病程迁延及肾病范围的蛋白尿,在首次就诊6个月后进行了肾活检,总体病理结果符合急性毛细血管内增生性肾小球肾炎。