家族性地中海热合并结节性多动脉炎及急性链球菌感染后肾小球肾炎的罕见表现。
Unusual presentation of familial Mediterranean fever with co-existing polyarteritis nodosa and acute post-streptococcal glomerulonephritis.
作者信息
Özdemir Atikel Yeşim, Derinkuyu Betül Emine, Bakkaloğlu Sevcan A
机构信息
Department of Pediatric Nephrology Gazi University Faculty of Medicine Ankara Turkey.
Department of Pediatric Radiology Gazi University Faculty of Medicine Ankara Turkey.
出版信息
Clin Case Rep. 2022 Jul 22;10(7):e6022. doi: 10.1002/ccr3.6022. eCollection 2022 Jul.
Acute post-streptococcal glomerulonephritis (APSGN) and polyarteritis nodosa (PAN) may occur simultaneously after streptococcal infection in a child who is previously healthy but carries a Mediterranean fever (MEFV) mutation. The homozygous M694V mutation in the MEFV gene may cause an augmented response to the streptococcal infection that plays a role in the development of both clinical manifestations.
急性链球菌感染后肾小球肾炎（APSGN）和结节性多动脉炎（PAN）可能在先前健康但携带地中海热（MEFV）突变的儿童发生链球菌感染后同时出现。MEFV基因中的纯合M694V突变可能导致对链球菌感染的反应增强，这在两种临床表现的发展中起作用。
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