Plouffe J F
Department of Internal Medicine, Ohio State University Hospitals, Columbus 43210.
J Antimicrob Chemother. 1989 Apr;23 Suppl D:85-8. doi: 10.1093/jac/23.suppl_d.85.
Patients undergoing elective abdominal surgery were randomized to receive cefmetazole or cefoxitin in a three-dose perioperative prophylactic regimen. There were three infections in 89 evaluable patients receiving cefmetazole. There were six infections in 39 patients receiving cefoxitin. Both regimens were acceptable with minimal toxicity.
接受择期腹部手术的患者被随机分配,在围手术期接受三剂量的头孢美唑或头孢西丁预防性治疗方案。在89例接受头孢美唑治疗的可评估患者中发生了3例感染。在39例接受头孢西丁治疗的患者中发生了6例感染。两种治疗方案均可接受,毒性极小。