Gaskill H V, Levine B A
University of Texas Health Science Center, Department of Surgery, San Antonio 78284-7842.
J Antimicrob Chemother. 1989 Apr;23 Suppl D:79-83. doi: 10.1093/jac/23.suppl_d.79.
The safety and efficacy of intravenous cefmetazole for prophylaxis before abdominal operations were compared with those of intravenous cefoxitin in a randomized, prospective clinical study. Eighty-nine evaluable patients were enrolled. These patients underwent primarily clean/contaminated (56%) and contaminated (39%) operations. A total of three (3%) patients developed postoperative wound infections. Two patients (2%) developed non-life-threatening adverse drug reactions. There were no life-threatening adverse drug reactions. There were no significant differences between the cefmetazole and cefoxitin study groups. Cefmetazole appears to be as safe and as efficacious as cefoxitin antibiotic in prophylaxis for intra-abdominal operations.
在一项随机、前瞻性临床研究中，对腹部手术前静脉注射头孢美唑与静脉注射头孢西丁的安全性和有效性进行了比较。共纳入89例可评估患者。这些患者主要接受清洁/污染手术（56%）和污染手术（39%）。共有3例（3%）患者发生术后伤口感染。2例（2%）患者出现无生命危险的药物不良反应。未出现危及生命的药物不良反应。头孢美唑组和头孢西丁组之间无显著差异。在预防腹腔内手术方面，头孢美唑似乎与头孢西丁抗生素一样安全有效。
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