LaPrade Robert F, Dragoo Jason L, Koh Jason L, Murray Iain R, Geeslin Andrew G, Chu Constance R
From the Steadman Philippon Research Institute, Vail, CO (Dr. LaPrade), Stanford University, Redwood City, CA (Dr. Dragoo and Dr. Chu), NorthShore University HealthSystem, Chicago, IL (Dr. Koh), the University of Edinburgh, Edinburgh, United Kingdom (Dr. Murray), and Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI (Dr. Geeslin).
J Am Acad Orthop Surg. 2016 Jul;24(7):e62-78. doi: 10.5435/JAAOS-D-16-00086.
Strategies that seek to enhance musculoskeletal tissue regeneration and repair by modulating the biologic microenvironment at the site of injury have considerable therapeutic potential. Current and emerging biologic approaches include the use of growth factors, platelet-rich plasma, stem cell therapy, and scaffolds. The American Academy of Orthopaedic Surgeons hosted a research symposium in November 2015 to review the current state-of-the-art biologic treatments of articular cartilage, muscle, tendon, and bone injuries and identify knowledge gaps related to these emerging treatments. This review outlines the findings of the symposium and summarizes the consensus reached on how best to advance research on biologic treatment of orthopaedic injuries.
通过调节损伤部位的生物微环境来促进肌肉骨骼组织再生和修复的策略具有巨大的治疗潜力。当前和新兴的生物方法包括使用生长因子、富血小板血浆、干细胞疗法和支架。美国骨科医师学会于2015年11月举办了一次研究研讨会,以回顾目前关节软骨、肌肉、肌腱和骨损伤的生物治疗的最新技术,并确定与这些新兴治疗相关的知识空白。本综述概述了研讨会的结果,并总结了就如何最好地推进骨科损伤生物治疗研究达成的共识。