Kim Hyeong Gon, Park Hyoung Keun, Paick Sung Hyun, Choi Woo Suk
Department of Urology, Konkuk University School of Medicine, Konkuk University Medical Center, Seoul, Korea.
PLoS One. 2016 May 26;11(5):e0156306. doi: 10.1371/journal.pone.0156306. eCollection 2016.
The aim of this study was to compare the two types of mid-urethral slings for stress urinary incontinence (SUI) with intrinsic sphincter deficiency (ISD).
This retrospective study included patients who underwent tension-free vaginal tape (TVT) procedure or transobturator tape (TOT) procedure by a single surgeon for SUI with ISD, defined as Valsalva leak point pressure (VLPP) < 60 cmH2O in a urodynamic study. Cases of neurogenic bladder, previous SUI surgery, and concomitant cystocele repair were excluded. The primary outcome was treatment success at 12 months, defined by self-reported absence of symptoms, no leakage episodes recorded, and no retreatment.
Among the 157 women who were included in the final analysis, 105 patients received TVT and 52 patients received TOT. Age, underlying diseases, Stamey grade, cystocele grade, and presence of urge incontinence were not significantly different between the two groups. Urodynamic parameters including maximal urethral closing pressure, detrusor overactivity, VLPP, urethral hypermobility (Q-tip ≥ 30°), were also comparable between the two groups. Success rate was significantly higher in the TVT group than in the TOT group (95.2% vs. 82.7%, p = 0.009). On multivariate analysis, only TOT surgery (OR = 3.922, 95%CI = 1.223-12.582, p = 0.022) was a risk factor for failure following surgical treatment.
TVT is more effective than TOT in treatment of female SUI with ISD.
本研究旨在比较两种用于治疗伴有固有括约肌缺陷(ISD)的压力性尿失禁(SUI)的尿道中段吊带。
这项回顾性研究纳入了由同一位外科医生为患有ISD的SUI患者进行无张力阴道吊带术(TVT)或经闭孔吊带术(TOT)的患者,ISD在尿动力学研究中定义为瓦尔萨尔瓦漏尿点压力(VLPP)<60 cmH₂O。排除神经源性膀胱病例、既往SUI手术史以及同时进行膀胱膨出修补术的病例。主要结局是12个月时的治疗成功,定义为自我报告无症状、无漏尿记录且无需再次治疗。
在最终纳入分析的157名女性中,105例患者接受了TVT,52例患者接受了TOT。两组在年龄、基础疾病、斯塔梅分级、膀胱膨出分级以及急迫性尿失禁的存在情况方面无显著差异。两组间包括最大尿道闭合压、逼尿肌过度活动、VLPP、尿道活动过度(棉签试验≥30°)在内的尿动力学参数也具有可比性。TVT组的成功率显著高于TOT组(95.2%对82.7%,p = 0.009)。多因素分析显示,只有TOT手术(OR = 3.922,95%CI = 1.223 - 12.582,p = 0.022)是手术治疗失败的危险因素。
在治疗伴有ISD的女性SUI方面,TVT比TOT更有效。