State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
College of Pharmaceutical Sciences, Zhejiang University , Hangzhou 310058, People's Republic of China.
Org Lett. 2016 Jun 17;18(12):2894-7. doi: 10.1021/acs.orglett.6b01213. Epub 2016 May 26.
Three new ring B-seco limonoids, ciliatonoids A-C (1-3), were isolated from Toona ciliate and structurally characterized by spectroscopic data, X-ray crystallography, and electronic circular dichroism analysis. Ciliatonoids A and B feature an unprecedented limonoid architecture, while ciliatonoid C belongs to a rare class of limonoids. Biological evaluation showed that compound 3 exhibited modest activities against the tested tumor cell lines.
从香椿中分离得到三个新的环 B-裂环柠檬苦素，即 ciliatonoids A-C（1-3），通过光谱数据、X 射线晶体学和电子圆二色性分析对其结构进行了表征。Ciliatonoids A 和 B 具有前所未有的柠檬苦素结构，而 ciliatonoid C 属于罕见的一类柠檬苦素。生物活性评价表明，化合物 3 对测试的肿瘤细胞系表现出中等活性。
