云南香椿叶中的柠檬苦素类化合物。

Limonoids from the leaves of Toona ciliata var. yunnanensis.

机构信息

State Key Laboratory of Photochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China.

出版信息

Phytochemistry. 2012 Apr;76:141-9. doi: 10.1016/j.phytochem.2012.01.002. Epub 2012 Jan 23.

DOI:10.1016/j.phytochem.2012.01.002

PMID:22277739

Abstract

Twelve limonoids, toonayunnanins A-L (1-12) and eleven known compounds (13-23) were isolated from the leaves of Toona ciliata var. yunnanensis, and their structures were elucidated by means of extensive spectroscopic analyses, particularly 1D and 2D NMR techniques. The inhibitory effects of all the isolated compounds were evaluated on human tumor cell lines, such as HL-60, SMMC-7721, A-549, MCF-7 and SW480. Cedrelone (13) and dysobinin (18) showed significant cytotoxicity, and toonayunnanin B (2) and epoxyazadiradione (14), were found to be slightly cytotoxic against the above cell lines. Furthermore, this study provides valuable information for the chemotaxonomy of T. ciliata varieties.

摘要

从云南香椿的叶子中分离得到 12 个倍半萜柠檬苦素，分别命名为 toonayunnanins A-L（1-12），并结合 1D 和 2D NMR 等波谱数据分析鉴定了它们的结构。还评价了所有分离得到的化合物对 HL-60、SMMC-7721、A-549、MCF-7 和 SW480 等人类肿瘤细胞系的抑制活性。结果表明，雪松醇（13）和 dysobinin（18）具有显著的细胞毒性，而 toonayunnanin B（2）和 epoxyazadiradione（14）对上述细胞系显示出轻微的细胞毒性。此外，本研究为香椿属植物的化学分类学提供了有价值的信息。