Atzeni Fabiola, Grillo Elisabetta, Masala Ignazio F, Sarzi-Puttini Piercarlo, Jones Gareth T
Isr Med Assoc J. 2016 Mar-Apr;18(3-4):154-5.
Lung involvement is a well-recognized extra-articular manifestation of ankylosing spondylitis (AS). Anecdotal reports suggest that the use of anti-TNF drugs may be related to lung disease and pulmonary fibrosis. To examine the association between anti-TNF drugs and the development of lung disease in patients with AS or psoriatic arthritis (PsA) we conducted a systematic review. Of the 670 papers identified by means of key word and hand search, only one full-text paper was considered potentially relevant but had to be discarded as it did not meet the eligibility criteria. Although no conclusion was reached, this is the first systematic review to examine this problem which is becoming increasingly important as these drugs are widely prescribed in patients with spondyloarthritis.
肺部受累是强直性脊柱炎（AS）一种公认的关节外表现。轶事报道表明，使用抗TNF药物可能与肺部疾病和肺纤维化有关。为了研究抗TNF药物与AS或银屑病关节炎（PsA）患者肺部疾病发生之间的关联，我们进行了一项系统评价。通过关键词和手工检索确定的670篇论文中，只有一篇全文论文被认为可能相关，但由于不符合纳入标准而不得不被舍弃。尽管未得出结论，但这是第一项研究此问题的系统评价，随着这些药物在脊柱关节炎患者中广泛应用，该问题正变得越来越重要。
