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与红皮病型银屑病相关的呼吸窘迫综合征

Respiratory Distress Syndrome Associated with Erythrodermic Psoriasis.

作者信息

Noure Lamya, Küçük Kirley, Simeni Njonnou Sylvain Raoul, Del Marmol Véronique, White Jonathan M, Bondue Benjamin

机构信息

Department of Pneumology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

出版信息

Case Rep Dermatol. 2021 Feb 4;13(1):83-88. doi: 10.1159/000511368. eCollection 2021 Jan-Apr.

DOI:10.1159/000511368
PMID:33708088
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7923713/
Abstract

Erythrodermic psoriasis is an uncommon and severe variant of psoriasis which may be associated with rare and severe complications such as acute respiratory distress syndrome. Early recognition of this life-threatening condition can allow prompt appropriate treatment. We report the case of a 69-year-old man with a long history of psoriasis who developed acute respiratory distress during a disease flare-up. There was no relevant past history (except for mild emphysema), known allergy, or recent treatment. Chest X-ray revealed new bilateral infiltrates, confirmed at chest computed tomography scan. Repeated cultures on aspirate of the bronchoalveolar lavage remained negative for viruses, bacteria, and parasites. Cardiac ultrasound was normal and high-dose corticosteroid therapy was initiated. Within a few days his clinical and radiological status improved significantly.

摘要

红皮病型银屑病是银屑病的一种罕见且严重的变体,可能与诸如急性呼吸窘迫综合征等罕见且严重的并发症相关。早期识别这种危及生命的病症可促使及时进行适当治疗。我们报告一例69岁男性病例,该患者有长期银屑病病史,在疾病发作期间出现急性呼吸窘迫。既往无相关病史(除轻度肺气肿外),无已知过敏史,近期也未接受治疗。胸部X线显示双侧新出现浸润影,胸部计算机断层扫描予以证实。支气管肺泡灌洗吸出物的反复培养结果显示病毒、细菌和寄生虫均为阴性。心脏超声检查正常,遂开始高剂量皮质类固醇治疗。数天内,他的临床和影像学状况显著改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabe/7923713/64c21500b264/cde-0013-0083-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabe/7923713/c3e15cec2109/cde-0013-0083-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabe/7923713/0f8ea8a05a04/cde-0013-0083-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabe/7923713/259e80dfe82c/cde-0013-0083-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabe/7923713/64c21500b264/cde-0013-0083-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabe/7923713/c3e15cec2109/cde-0013-0083-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabe/7923713/0f8ea8a05a04/cde-0013-0083-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabe/7923713/259e80dfe82c/cde-0013-0083-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eabe/7923713/64c21500b264/cde-0013-0083-g04.jpg

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本文引用的文献

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Psoriasis Pathogenesis and Treatment.银屑病发病机制与治疗。
Int J Mol Sci. 2019 Mar 23;20(6):1475. doi: 10.3390/ijms20061475.
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How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis?血管内皮生长因子和细胞间黏附分子在银屑病系统性毛细血管渗漏综合征中具有怎样的相关性?
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评价斑块状、脓疱状和红皮病性银屑病患者皮肤中细胞间黏附分子-1 的表达和血管变化。
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