Han D K, Park K D, Ahn K D, Jeong S Y, Kim Y H
Polymer Chemistry Laboratory, Korea Advanced Institute of Science and Technology, Cheongryang, Seoul.
J Biomed Mater Res. 1989 Apr;23(A1 Suppl):87-104. doi: 10.1002/jbm.820231309.
Surfaces of commercial polyurethanes (PUs) were modified by poly(ethylene oxide) (PEO) grafting and/or heparin immobilization for long-term biomedical applications. PU surfaces were treated with diisocyanate and then reacted with PEO or heparin. The heparin immobilized by various methods on the PU surface was very stable, with concentrations of 1.45-1.84 micrograms/cm2. Surface structure and characteristics of each modified PU were examined by performing the following surface analyses: attenuated total reflection infrared (ATR-IR), electron spectroscopy for chemical analysis (ESCA), scanning electron microscopy (SEM), and dynamic contact angle measurements. The reaction scheme and surface chemical structure of modified PUs were confirmed by ATR-IR and ESCA, respectively. SEM results showed that the PU-PEO surface was very smooth and that the smoothness of the heparinized PU surfaces varied, depending upon the solvent and coupling agent used in the process. The hydrophilicity of the surface was significantly increased after PEO grafting or heparin immobilization. Increase in the chain length of the grafted PEO resulted in significant increases in hydrophilicity and surface mobility.
为实现长期生物医学应用，通过聚环氧乙烷（PEO）接枝和/或肝素固定化对商用聚氨酯（PU）表面进行了改性。PU表面先用二异氰酸酯处理，然后与PEO或肝素反应。通过各种方法固定在PU表面的肝素非常稳定，浓度为1.45 - 1.84微克/平方厘米。通过进行以下表面分析来检查每种改性PU的表面结构和特性：衰减全反射红外光谱（ATR-IR）、化学分析电子能谱（ESCA）、扫描电子显微镜（SEM）和动态接触角测量。改性PU的反应方案和表面化学结构分别通过ATR-IR和ESCA得到证实。SEM结果表明，PU-PEO表面非常光滑，而肝素化PU表面的光滑程度有所不同，这取决于该过程中使用的溶剂和偶联剂。PEO接枝或肝素固定化后，表面亲水性显著增加。接枝PEO链长的增加导致亲水性和表面流动性显著提高。
