Murrell G A, Francis M J, Howlett C R
Nuffield Orthopaedic Centre, Oxford, England.
J Bone Joint Surg Br. 1989 May;71(3):367-73. doi: 10.1302/0301-620X.71B3.2722922.
The fine structure of palmar fascia from patients with Dupuytren's contracture (DC) was compared with that from patients with carpal tunnel syndrome (CTS). In contrast to previous assumptions, the ultrastructure of fibroblasts both in vivo and in vitro from DC and CTS appeared identical, indicating that myofibroblasts are not specific to DC. The major differences between DC and CTS were: 1) a sixfold and fortyfold increase in fibroblast density in cord and nodular areas of DC compared with CTS; 2) a more disorganised pattern of collagen fibrils in DC; and 3) markedly narrowed microvessels surrounded by thickened, laminated basal laminae and proliferating fibroblasts in DC compared with CTS. To account for these morphological changes a hypothesis is presented which proposes that oxygen-free radicals cause pericytic necrosis and fibroblastic proliferation. This hypothesis provides a potential avenue for therapy of DC and other fibrotic conditions.
将掌腱膜挛缩症（DC）患者的掌腱膜精细结构与腕管综合征（CTS）患者的进行了比较。与先前的假设相反，DC和CTS患者体内和体外的成纤维细胞超微结构看起来相同，这表明肌成纤维细胞并非DC所特有。DC和CTS之间的主要差异在于：1）与CTS相比，DC的条索状和结节状区域中成纤维细胞密度增加了6倍和40倍；2）DC中胶原纤维的排列模式更紊乱；3）与CTS相比，DC中微血管明显变窄，周围有增厚的层状基底膜和增殖的成纤维细胞。为了解释这些形态学变化，提出了一个假说，即氧自由基导致周细胞坏死和成纤维细胞增殖。该假说为DC和其他纤维化疾病的治疗提供了一条潜在途径。
