自由基与掌腱膜挛缩症
Free radicals and Dupuytren's contracture.
作者信息
Murrell G A, Francis M J, Bromley L
机构信息
Nuffield Department of Orthopaedic Surgery, University of Oxford.
出版信息
Br Med J (Clin Res Ed). 1987 Nov 28;295(6610):1373-5. doi: 10.1136/bmj.295.6610.1373.
The concentration of substrate expressed as hypoxanthine capable of reacting with xanthine oxidase to release superoxide free radicals (O2-) was measured in control and Dupuytren's contracture palmar fascia. In Dupuytren's contracture palmar fascia the concentration of hypoxanthine was six times that of control and was greatest in "nodular" areas. Xanthine oxidase activity was also detected in Dupuytren's contracture palmar fascia. These results suggest a greater potential for hypoxanthine-xanthine oxidase generated oxygen free radical formation in Dupuytren's contracture than in control palmar fascia. Production of free radicals may be an important factor in the pathogenesis of Dupuytren's contracture. The benefit of allopurinol in the management of Dupuytren's contracture and other fibrotic conditions may thus be explained, as allopurinol binds to xanthine oxidase and prevents release of free radicals.
在对照和掌腱膜挛缩的掌腱膜中，测量了以次黄嘌呤形式表示的底物浓度，该底物能够与黄嘌呤氧化酶反应释放超氧阴离子自由基（O2-）。在掌腱膜挛缩的掌腱膜中，次黄嘌呤的浓度是对照的六倍，并且在“结节”区域最高。在掌腱膜挛缩的掌腱膜中也检测到黄嘌呤氧化酶活性。这些结果表明，与对照掌腱膜相比，掌腱膜挛缩中次黄嘌呤 - 黄嘌呤氧化酶产生氧自由基的潜力更大。自由基的产生可能是掌腱膜挛缩发病机制中的一个重要因素。因此，别嘌呤醇在掌腱膜挛缩和其他纤维化疾病治疗中的益处可以得到解释，因为别嘌呤醇与黄嘌呤氧化酶结合并阻止自由基的释放。
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