Semler Matthew W, Rice Todd W
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Medical Center North, T-1218, Nashville, TN 37232-2650, USA.
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Medical Center North, T-1218, Nashville, TN 37232-2650, USA.
Clin Chest Med. 2016 Jun;37(2):241-50. doi: 10.1016/j.ccm.2016.01.007. Epub 2016 Mar 4.
Sepsis is a common and life-threatening inflammatory response to severe infection treated with antibiotics and fluid resuscitation. Despite the central role of intravenous fluid in sepsis management, fundamental questions regarding which fluid and in what amount remain unanswered. Recent advances in understanding the physiologic response to fluid administration, and large clinical studies examining resuscitation strategies, fluid balance after resuscitation, colloid versus crystalloid solutions, and high- versus low-chloride crystalloids, inform the current approach to sepsis fluid management and suggest areas for future research.
脓毒症是一种对严重感染常见且危及生命的炎症反应，通过抗生素和液体复苏进行治疗。尽管静脉输液在脓毒症管理中起着核心作用，但关于使用哪种液体以及使用多少量等基本问题仍未得到解答。在理解对液体输注的生理反应方面的最新进展，以及大量研究复苏策略、复苏后液体平衡、胶体溶液与晶体溶液以及高氯与低氯晶体溶液的临床研究，为当前脓毒症液体管理方法提供了依据，并指出了未来研究的方向。
