开放式手术环境中荧光相机的（混合）导航
Toward (Hybrid) Navigation of a Fluorescence Camera in an Open Surgery Setting.
作者信息
KleinJan Gijs H, van den Berg Nynke S, van Oosterom Matthias N, Wendler Thomas, Miwa Mitsuharu, Bex Axel, Hendricksen Kees, Horenblas Simon, van Leeuwen Fijs W B
机构信息
Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands Department of Nuclear Medicine, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands Department of Urology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
出版信息
J Nucl Med. 2016 Oct;57(10):1650-1653. doi: 10.2967/jnumed.115.171645. Epub 2016 May 26.
UNLABELLED
With the introduction of the hybrid tracer indocyanine green (ICG)-Tc-nanocolloid, a direct relation between preoperative imaging and intraoperative fluorescence guidance was established. However, fluorescence guidance remains limited by its superficial nature. This study evaluated the feasibility of a nuclear medicine-based navigation concept that allowed intraoperative positioning of a fluorescence camera (FC) in the vicinity of preoperatively defined ICG-Tc-nanocolloid containing sentinel nodes (SNs).
METHODS
Five patients with penile cancer scheduled for SN biopsy were injected with ICG-Tc-nanocolloid followed by preoperative SPECT/CT imaging. The navigation device was used to provide a real-time augmented reality overlay of the SPECT/CT images and video output of the FC. This overlay was then used for FC navigation.
RESULTS
SPECT/CT identified 13 SNs in 9 groins. FC navigation was successful for all 12 intraoperatively evaluated SNs (average error, 8.8 mm; range, 0-20 mm).
CONCLUSION
This study reveals the potential benefits of FC navigation during open surgery procedures.
未标注
随着混合示踪剂吲哚菁绿（ICG）-锝纳米胶体的引入，术前成像与术中荧光引导之间建立了直接联系。然而，荧光引导仍受其表面性质的限制。本研究评估了一种基于核医学的导航概念的可行性，该概念允许在术前定义的含有前哨淋巴结（SNs）的ICG-锝纳米胶体附近进行术中荧光相机（FC）定位。
方法
5例计划进行SN活检的阴茎癌患者注射ICG-锝纳米胶体，随后进行术前SPECT/CT成像。使用导航设备提供SPECT/CT图像和FC视频输出的实时增强现实叠加。然后将该叠加用于FC导航。
结果
SPECT/CT在9个腹股沟区识别出13个SNs。FC导航对所有12个术中评估的SNs均成功（平均误差8.8mm；范围0-20mm）。
结论
本研究揭示了FC导航在开放手术过程中的潜在益处。
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