Institute of Medical Technology, Peking University Health Science Center, Beijing, 100080, China.
First Clinical Medical College, Nanjing Medical University, Nanjing, 210000, China.
World J Urol. 2023 Sep;41(9):2319-2326. doi: 10.1007/s00345-023-04485-x. Epub 2023 Jul 7.
The aim of this study was to investigate the overall sensitivity and specificity of indocyanine green (ICG)-near-infrared (NIR) fluorescence imaging in the detection of sentinel lymph node metastasis (SLNM) in penile cancer.
We searched PubMed, Embase, Web of Science, Scopus, and the Cochrane Library databases to identify manuscripts where ICG was intravenously administered prior to or during penile cancer surgery, with no restriction on language or publication status. The results extracted are presented as forest plots.
Seven studies were included in the analysis. The median sensitivity and specificity of ICG-NIR imaging for SLNM detection were 100 and 4%, respectively; the pooled sensitivity was 100.0% (95% confidence interval [CI] 97.0-100.0) and specificity was 2.0% (95% CI 1.0-3.0). There was no significant difference in the diagnostic results between different injection sites and doses in each experimental group.
To our knowledge, this meta-analysis is the first to summarize the diagnostic performance of ICG-NIR imaging for SLNM detection in penile cancer. ICG is sensitive in the imaging of SLN tissue, which can consequently improve the accuracy of lymph node detection. However, the specificity is very low.
本研究旨在探讨吲哚菁绿（ICG）-近红外（NIR）荧光成像在检测阴茎癌前哨淋巴结转移（SLNM）中的总体敏感性和特异性。
我们检索了 PubMed、Embase、Web of Science、Scopus 和 Cochrane Library 数据库，以确定在阴茎癌手术前或手术期间静脉注射 ICG 的文献，不限制语言或发表状态。提取的结果以森林图呈现。
共纳入 7 项研究。ICG-NIR 成像检测 SLNM 的中位敏感性和特异性分别为 100%和 4%；汇总敏感性为 100.0%（95%置信区间[CI]97.0-100.0），特异性为 2.0%（95%CI1.0-3.0）。在每个实验组中，不同注射部位和剂量的诊断结果没有显著差异。
据我们所知，这是第一项总结 ICG-NIR 成像在阴茎癌 SLNM 检测中的诊断性能的荟萃分析。ICG 对 SLN 组织的成像很敏感，从而提高了淋巴结检测的准确性。然而，特异性非常低。
