Fujimura A, Ebihara A, Hino N, Koike Y
Department of Clinical Pharmacology, Oita Medical School, Japan.
J Clin Pharmacol. 1989 Apr;29(4):327-30. doi: 10.1002/j.1552-4604.1989.tb03336.x.
The effects of chronic administration of traxanox sodium (traxanox) on blood pressure and serum uric acid level were investigated in 15 patients who had mild to moderate hypertension. Traxanox or its placebo was orally administered in a single-blind protocol. Blood pressure was significantly reduced from baseline after treatment with traxanox. The serum uric acid level after drug administration was significantly lower than with placebo whereas urinary uric acid excretion was significantly greater and uric acid clearance tended to be greater. These results indicate that chronic administration of traxanox reduces serum uric acid level as well as blood pressure in patients with mild to moderate hypertension. This reduction in serum uric acid is due in part to a traxanox-induced elevation of urinary uric acid excretion.
在15例轻度至中度高血压患者中研究了慢性给予曲克索钠（traxanox）对血压和血清尿酸水平的影响。采用单盲方案口服给予曲克索钠或其安慰剂。用曲克索钠治疗后血压较基线显著降低。给药后血清尿酸水平显著低于安慰剂，而尿尿酸排泄显著增加，尿酸清除率也有增加趋势。这些结果表明，慢性给予曲克索钠可降低轻度至中度高血压患者的血清尿酸水平和血压。血清尿酸的降低部分归因于曲克索钠引起的尿尿酸排泄增加。
