眼灌注压的日曲线

Diurnal Curve of the Ocular Perfusion Pressure.

作者信息

Kanadani Fabio N, Moreira Tca, Bezerra Bsp, Vianello M P, Corradi J, Dorairaj S K, Prata T S

机构信息

Chief, Department of Glaucoma, Medical Science University Hospital, Belo Horizonte, Brazil.

Assistant Professor, Department of Retina, Medical Science University Hospital, Belo Horizonte, Brazil.

出版信息

J Curr Glaucoma Pract. 2016 Jan-Apr;10(1):4-6. doi: 10.5005/jp-journals-10008-1195. Epub 2016 May 12.

DOI:10.5005/jp-journals-10008-1195

PMID:27231413

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4875728/

Abstract

PURPOSE

To describe the diurnal variation of the ocular perfusion pressure (OPP) in normal, suspects and glaucoma patients.

MATERIALS AND METHODS

Seventy-nine subjects were enrolled in a prospective study. The diurnal curve of intraocular pressure (IOP) was performed and blood pressure measurements were obtained. Each participant was grouped into one of the following based upon the clinical evaluation of the optic disk, IOP and standard achromatic perimetry (SAP): 18 eyes were classified as normal (normal SAP, normal optic disk evaluation and IOP < 21 mm Hg in two different measurements), 30 eyes as glaucoma suspect (GS) (normal SAP and mean deviation (MD), C/D ration > 0.5 or asymmetry > 0.2 and/or ocular hypertension), 31 eyes as early glaucoma (MD < -6 dB, glaucomatous optic neuropathy and SAP and MDs on SAP. Standard achromatic perimetry was performed with the Octopus 3.1.1 Dynamic 24-2 program. Intraocular pressure and blood pressure measurements were taken at 6 am, 9 am, 12, 3 and 6 pm. The patients stayed in the seated position for 5 minutes prior to blood pressure measurements.

RESULTS

The mean IOP values in all groups did not follow any regular pattern. The peak IOP was found to be greater in suspect [18.70 ± 3.31 (mm Hg ± SD)] and glaucoma (18.77 ± 4.30 mm Hg) patients as compared to normal subjects (16.11 ± 2.27 mm Hg). In studying the diurnal variation of the OPP, we found lower values at 3 pm in normals (34.21 ± 2.07 mm Hg), at 9 am in suspects (54.35 ± 3.32 mm Hg) and at 12 pm in glaucoma patients (34.84 ± 1.44 mm Hg).

CONCLUSION

Each group has a specific OPP variation during the day with the most homogeneous group being the suspect one. It is important to keep studying the IOP and OPP variation for increased comprehension of the pathophysiology of glaucomatous optic neuropathy. How to cite this article: Kanadani FN, Moreira TCA, Bezerra BSP, Vianello MP, Corradi J, Dorairaj SK, Prata TS. Diurnal Curve of the Ocular Perfusion Pressure. J Curr Glaucoma Pract 2016;10(1):4-6.

摘要

目的

描述正常、可疑青光眼和青光眼患者眼灌注压（OPP）的昼夜变化。

材料与方法

79名受试者纳入一项前瞻性研究。测量眼压（IOP）的昼夜曲线并获取血压测量值。根据视盘、IOP和标准彩色视野检查（SAP）的临床评估，将每位参与者分为以下类别之一：18只眼被分类为正常（正常SAP、正常视盘评估且两次不同测量时IOP < 21 mmHg），30只眼为青光眼可疑（GS）（正常SAP和平均偏差（MD）、C/D比值> 0.5或不对称性> 0.2和/或高眼压），31只眼为早期青光眼（MD < -6 dB、青光眼性视神经病变以及SAP和SAP上的MDs）。使用Octopus 3.1.1动态24 - 2程序进行标准彩色视野检查。在上午6点、9点、12点、下午3点和6点测量眼压和血压。患者在测量血压前保持坐姿5分钟。

结果

所有组的平均IOP值未呈现任何规律模式。与正常受试者（16.11 ± 2.27 mmHg）相比，可疑青光眼患者[18.70 ± 3.31（mmHg ± SD）]和青光眼患者（18.77 ± 4.30 mmHg）的IOP峰值更高。在研究OPP的昼夜变化时，我们发现正常受试者在下午3点时OPP值较低（34.21 ± 2.07 mmHg），可疑青光眼患者在上午9点时较低（54.35 ± 3.32 mmHg），青光眼患者在中午12点时较低（34.84 ± 1.44 mmHg）。

结论

每组在一天中都有特定的OPP变化，最具同质性的组是可疑青光眼组。持续研究IOP和OPP变化对于加深对青光眼性视神经病变病理生理学的理解很重要。如何引用本文：Kanadani FN, Moreira TCA, Bezerra BSP, Vianello MP, Corradi J, Dorairaj SK, Prata TS. 眼灌注压的昼夜曲线。《当代青光眼实践杂志》2016；10(1):4 - 6。