Yun Hong-min, Fu Pei, Yuan Jin-song, Zhang Bin, Li Xiao-xin
Department of Ophthalmology, Shenzhen Hospital, Peking University, Shenzhen 518036, China.
Zhonghua Yi Xue Za Zhi. 2006 Dec 26;86(48):3401-4.
To observe the diurnal variations of intraocular pressure (IOP) measured with dynamic contour tonometer (DCT) in primary open angle glaucoma (POAG) patients, normal tension glaucoma (NTG) patients, and healthy controls, and to compare the differences of diurnal variation curves between the two eyes of each subject and define the distribution of the peak of IOP; to analyze the diurnal variation range of ocular pulse amplitude (OPA) and compare the differences among the POAG and NTG patients and healthy controls.
DCT was used to measure the diurnal variations of IOP and OPA in the two eyes of 18 POAG patients, 17 NTG patients and 30 normal controls at 5:00, 7:00, 10:00, 14:00, 18:00, and 22:00 and the distribution of the peak IOP was observed. The range of the diurnal variation of OPA was identified.
The diurnal variation curves of IOP were different among the POAG patients, NTG patients, and normal people, and also between the two eyes of each subject. Four right eyes (13.3%) and 6 left eyes (20.0%) of the healthy controls, 4 right eyes (23.5%) and 5 left eyes (29.4%) of the NTG patients, and 5 right eyes (27.8%) and 4 left eyes (22.2%) of the POAG patients reached the peak IOP values in out-office period. Diurnal variation of OPA was detected in both the patients and controls, and the variation curves were different within different groups sampled and between the two eyes of each subject. The diurnal OPA range of the right and left eyes of the POAG group were (2.1 +/- 1.3) mm Hg, and (2.4 +/- 1.9) mm Hg respectively, significantly larger than those of the normal controls [(1.1 +/- 0.5) mm Hg and 1.2 +/- 0.5) mm Hg respectively], and those of the NTG group [(1.1 +/- 0.8) mm Hg and (1.0 +/- 0.5) mm Hg) respectively] (all P < 0.01).
OPA has diurnal variation. The diurnal variation of the POAG patients is the largest. NTG patients and normal controls have asymmetric IOP and OPA diurnal variations. The two eyes of the same individual cannot always be treated as the same. The value of IOP measured in the office-time cannot completely represents the 1 d IOP.
观察原发性开角型青光眼（POAG）患者、正常眼压性青光眼（NTG）患者及健康对照者使用动态轮廓眼压计（DCT）测量的眼压（IOP）昼夜变化情况，比较各受试者双眼间昼夜变化曲线的差异并确定眼压峰值分布；分析眼脉动幅度（OPA）的昼夜变化范围，比较POAG患者、NTG患者与健康对照者之间的差异。
使用DCT在5:00、7:00、10:00、14:00、18:00和22:00测量18例POAG患者、17例NTG患者和30例正常对照者双眼的IOP和OPA昼夜变化情况，并观察眼压峰值分布。确定OPA的昼夜变化范围。
POAG患者、NTG患者和正常人的IOP昼夜变化曲线不同，各受试者双眼间也不同。健康对照者4只右眼（13.3%）和6只左眼（20.0%）、NTG患者4只右眼（23.5%）和5只左眼（29.4%）、POAG患者5只右眼（27.8%）和4只左眼（22.2%）在非就诊时段达到眼压峰值。患者和对照者均检测到OPA的昼夜变化，不同采样组内及各受试者双眼间变化曲线不同。POAG组右眼和左眼的昼夜OPA范围分别为（2.1±1.3）mmHg和（2.4±1.9）mmHg，显著大于正常对照组[分别为（1.1±0.5）mmHg和（1.2±0.5）mmHg]以及NTG组[分别为（1.1±0.8）mmHg和（1.0±0.5）mmHg]（均P<0.01）。
OPA存在昼夜变化。POAG患者的昼夜变化最大。NTG患者和正常对照者的IOP和OPA昼夜变化不对称。同一个体的双眼不能总是被视为相同情况。就诊时测量的眼压值不能完全代表一天的眼压情况。
