Shuba Lesya M, Doan Andrew P, Maley Michael K, Zimmerman M Bridget, Dinn Robert B, Greenlee Emily C, Alward Wallace L M, Kwon Young H
Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
J Glaucoma. 2007 May;16(3):307-12. doi: 10.1097/IJG.0b013e3180316736.
The study objective was to determine the concordance of intraocular pressure (IOP) in glaucoma suspects (GS) and normal tension glaucoma (NTG) patients.
This was a retrospective review of diurnal curves of untreated GS and NTG patients. No subject had IOP greater than 21 mm Hg. We defined GS patients as having suspicious optic nerves with normal visual fields, and NTG patients as having glaucomatous optic nerves with associated visual field loss. Goldmann applanation tonometry was performed at 10:00, 13:00, 16:00, 19:00, 22:00, and 07:00. Linear association of OD and OS IOP was estimated using Pearson correlation coefficient (r). The diurnal period was divided into 7 time intervals of 3, 6, 9, 12, 15, 18, and 21 hours, and the absolute difference in change in IOP between fellow eyes and probability that it was within 3 mm Hg were calculated.
The study included 68 GS and 95 NTG subjects. The diurnal curves of the OD and OS showed a parallel course in both groups. The average correlations (r) of OD and OS IOP over the 6 time points were 0.78 and 0.81 for GS and NTG, respectively. The mean absolute difference in IOP change between OD and OS over the 6 time intervals ranged between 1.4 and 1.9 mm Hg for GS, and 1.3 and 1.5 mm Hg for NTG subjects. The probability that this difference was within 3 mm Hg ranged between 87% and 94% for GS, and 86% and 93% for NTG subjects.
The diurnal variation in IOP between the 2 eyes in GS and NTG is largely concordant in approximately 90% of the time.
本研究的目的是确定青光眼可疑患者（GS）和正常眼压性青光眼（NTG）患者眼内压（IOP）的一致性。
这是一项对未经治疗的GS和NTG患者昼夜眼压曲线的回顾性研究。所有受试者的眼压均不高于21 mmHg。我们将GS患者定义为具有可疑视神经且视野正常的患者，将NTG患者定义为具有青光眼性视神经并伴有视野缺损的患者。于10:00、13:00、16:00、19:00、22:00和07:00使用Goldmann压平眼压计进行测量。使用Pearson相关系数（r）估计右眼（OD）和左眼（OS）眼压的线性相关性。将昼夜周期分为7个时间间隔，分别为3、6、9、12、15、18和21小时，并计算双眼眼压变化的绝对差值及其在3 mmHg以内的概率。
该研究纳入了68名GS受试者和95名NTG受试者。两组中OD和OS的昼夜眼压曲线均呈平行趋势。GS组和NTG组在6个时间点上OD和OS眼压的平均相关性（r）分别为0.78和0.81。在6个时间间隔内，GS组OD和OS眼压变化的平均绝对差值在1.4至1.9 mmHg之间，NTG组在1.3至1.5 mmHg之间。GS组该差值在3 mmHg以内的概率在87%至94%之间，NTG组在86%至93%之间。
GS和NTG患者两眼之间的眼压昼夜变化在大约90%的时间内基本一致。
